Enhanced therapeutic efficacy of iRGD-conjugated crosslinked multilayer liposomes for drug delivery

Yarong Liu, Man Ji, Michael K. Wong, Kye Il Joo, Pin Wang

Research output: Contribution to journalArticlepeer-review

55 Scopus citations

Abstract

Targeting nanoparticles by conjugating various specific ligands has shown potential therapeutic efficacy in nanomedicine. However, poor penetration of antitumor drugs into solid tumors remains a major obstacle. Here, we describe a targeting strategy for antitumor drug delivery by conjugating a crosslinked multilamellar liposomal vesicle (cMLV) formulation with a tumor-penetrating peptide, iRGD. The results showed that iRGD peptides could facilitate the binding and cellular uptake of drug-loaded cMLVs and consequently enhance the antitumor efficacy in breast tumor cells, including multidrug-resistant cells. Moreover, colocalization data revealed that iRGD-conjugated cMLVs (iRGD-cMLVs) entered cells via the clathrin-mediated pathway, followed by endosome-lysosome transport for efficient drug delivery. Finally, in vivo study indicated that iRGD-cMLVs could deliver anticancer drugs efficiently to mediate significant tumor suppression.

Original languageEnglish
Article number378380
JournalBioMed Research International
Volume2013
DOIs
StatePublished - 2013

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