Enhanced expression of neuronal nitric oxide synthase and phospholipase C-γ1 in regenerating murine neuronal cells by pulsed electromagnetic field

Sung Sook Kim; Hye Jung Shin; Dae Woon Eom; Joo Ryung Huh; Yeongju Woo; Hyokyung Kim; Sung Ho Ryu; Pann Gil Suh; Moon Jung Kim; Jee Yun Kim; Tae Wan Koo; Yoon Hee Cho; Sung Min Chung

doi:10.1038/emm.2002.8

Enhanced expression of neuronal nitric oxide synthase and phospholipase C-γ1 in regenerating murine neuronal cells by pulsed electromagnetic field

Sung Sook Kim, Hye Jung Shin, Dae Woon Eom, Joo Ryung Huh, Yeongju Woo, Hyokyung Kim, Sung Ho Ryu, Pann Gil Suh, Moon Jung Kim, Jee Yun Kim, Tae Wan Koo, Yoon Hee Cho, Sung Min Chung

Department of Otolaryngology

Research output: Contribution to journal › Article › peer-review

38 Scopus citations

Abstract

Pulsed electromagnetic field (PEMF) has been shown to improve the rate of peripheral nerve regeneration. In the present study we investigated the expression of neuronal nitric oxide synthase (nNOS) and phospholipase C-γ1 (PLC-γ1) in regenerating rat laryngeal nerves during the exposure to PEMF after surgical transection and reanastomosis. Axons were found to regenerate into the distal stump nearly twice faster in PEMF-exposed animals than in the control. Consistently, motor function was better recovered in PEMF-treated rats. The expression of nNOS and PLC-γ1 was highly enhanced in the regenerated nerves.

Original language	English
Pages (from-to)	53-59
Number of pages	7
Journal	Experimental and Molecular Medicine
Volume	34
Issue number	1
DOIs	https://doi.org/10.1038/emm.2002.8
State	Published - 31 Mar 2002

Keywords

NOS
PEMF
PLC-γ1
S-100

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Kim, S. S., Shin, H. J., Eom, D. W., Huh, J. R., Woo, Y., Kim, H., Ryu, S. H., Suh, P. G., Kim, M. J., Kim, J. Y., Koo, T. W., Cho, Y. H., & Chung, S. M. (2002). Enhanced expression of neuronal nitric oxide synthase and phospholipase C-γ1 in regenerating murine neuronal cells by pulsed electromagnetic field. Experimental and Molecular Medicine, 34(1), 53-59. https://doi.org/10.1038/emm.2002.8

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abstract = "Pulsed electromagnetic field (PEMF) has been shown to improve the rate of peripheral nerve regeneration. In the present study we investigated the expression of neuronal nitric oxide synthase (nNOS) and phospholipase C-γ1 (PLC-γ1) in regenerating rat laryngeal nerves during the exposure to PEMF after surgical transection and reanastomosis. Axons were found to regenerate into the distal stump nearly twice faster in PEMF-exposed animals than in the control. Consistently, motor function was better recovered in PEMF-treated rats. The expression of nNOS and PLC-γ1 was highly enhanced in the regenerated nerves.",

keywords = "NOS, PEMF, PLC-γ1, S-100",

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Kim, SS, Shin, HJ, Eom, DW, Huh, JR, Woo, Y, Kim, H, Ryu, SH, Suh, PG, Kim, MJ, Kim, JY, Koo, TW, Cho, YH & Chung, SM 2002, 'Enhanced expression of neuronal nitric oxide synthase and phospholipase C-γ1 in regenerating murine neuronal cells by pulsed electromagnetic field', Experimental and Molecular Medicine, vol. 34, no. 1, pp. 53-59. https://doi.org/10.1038/emm.2002.8

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AU - Kim, Sung Sook

AU - Shin, Hye Jung

AU - Eom, Dae Woon

AU - Huh, Joo Ryung

AU - Woo, Yeongju

AU - Kim, Hyokyung

AU - Ryu, Sung Ho

AU - Suh, Pann Gil

AU - Kim, Moon Jung

AU - Kim, Jee Yun

AU - Koo, Tae Wan

AU - Cho, Yoon Hee

AU - Chung, Sung Min

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AB - Pulsed electromagnetic field (PEMF) has been shown to improve the rate of peripheral nerve regeneration. In the present study we investigated the expression of neuronal nitric oxide synthase (nNOS) and phospholipase C-γ1 (PLC-γ1) in regenerating rat laryngeal nerves during the exposure to PEMF after surgical transection and reanastomosis. Axons were found to regenerate into the distal stump nearly twice faster in PEMF-exposed animals than in the control. Consistently, motor function was better recovered in PEMF-treated rats. The expression of nNOS and PLC-γ1 was highly enhanced in the regenerated nerves.

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KW - PEMF

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Enhanced expression of neuronal nitric oxide synthase and phospholipase C-γ1 in regenerating murine neuronal cells by pulsed electromagnetic field

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Keywords

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