Enhanced delivery of the phototherapeutic nanoparticles via hepatocyte overload

Jae Yeon Kim; Ye Chan Kil; Da Hye Yang; Dal Yong Park; Hee Jun Jang; Song Kyu Park; Yong Woo Jung; Hong Yeol Yoon; Kwangmeyung Kim; Daesub Song; Soon Hong Yuk

doi:10.1016/j.colsurfb.2022.112959

Enhanced delivery of the phototherapeutic nanoparticles via hepatocyte overload

Jae Yeon Kim, Ye Chan Kil, Da Hye Yang, Dal Yong Park, Hee Jun Jang, Song Kyu Park, Yong Woo Jung, Hong Yeol Yoon, Kwangmeyung Kim, Daesub Song, Soon Hong Yuk

Department of Pharmaceutical Sciences

Research output: Contribution to journal › Article › peer-review

Abstract

Phototherapeutic nanoparticles (NPs) were prepared with methylene blue (MB), indocyanine green (ICG), and Solutol through self-assembly. Generation of reactive oxygen species and elevation of temperature were observed that verify the photodynamic/photothermal effects of the NPs. Morphology and size distribution of the NPs were examined by transmittance electron microscopy and dynamic light scattering. The biodistribution of the NPs and their antitumor efficacy were examined using tumor-bearing mice to understand the phototherapeutic effect of the NPs on tumors. To enhance targetability with enhanced therapeutic efficacy, empty NPs (Solutol nanoparticles without MB and ICG) at different concentrations were injected along with the phototherapeutic NPs. Enhanced delivery of the phototherapeutic NPs at the tumor site was examined based on hepatocyte overload.

Original language	English
Article number	112959
Journal	Colloids and Surfaces B: Biointerfaces
Volume	221
DOIs	https://doi.org/10.1016/j.colsurfb.2022.112959
State	Published - Jan 2023

Bibliographical note

Publisher Copyright:
© 2022 Elsevier B.V.

Keywords

Hepatocyte overload
Indocyanine green
Methylene blue
Phototheraputic nanoparticles
Solutol

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10.1016/j.colsurfb.2022.112959

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title = "Enhanced delivery of the phototherapeutic nanoparticles via hepatocyte overload",

abstract = "Phototherapeutic nanoparticles (NPs) were prepared with methylene blue (MB), indocyanine green (ICG), and Solutol through self-assembly. Generation of reactive oxygen species and elevation of temperature were observed that verify the photodynamic/photothermal effects of the NPs. Morphology and size distribution of the NPs were examined by transmittance electron microscopy and dynamic light scattering. The biodistribution of the NPs and their antitumor efficacy were examined using tumor-bearing mice to understand the phototherapeutic effect of the NPs on tumors. To enhance targetability with enhanced therapeutic efficacy, empty NPs (Solutol nanoparticles without MB and ICG) at different concentrations were injected along with the phototherapeutic NPs. Enhanced delivery of the phototherapeutic NPs at the tumor site was examined based on hepatocyte overload.",

keywords = "Hepatocyte overload, Indocyanine green, Methylene blue, Phototheraputic nanoparticles, Solutol",

author = "Kim, {Jae Yeon} and Kil, {Ye Chan} and Yang, {Da Hye} and Park, {Dal Yong} and Jang, {Hee Jun} and Park, {Song Kyu} and Jung, {Yong Woo} and Yoon, {Hong Yeol} and Kwangmeyung Kim and Daesub Song and Yuk, {Soon Hong}",

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year = "2023",

month = jan,

doi = "10.1016/j.colsurfb.2022.112959",

language = "English",

volume = "221",

journal = "Colloids and Surfaces B: Biointerfaces",

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T1 - Enhanced delivery of the phototherapeutic nanoparticles via hepatocyte overload

AU - Kim, Jae Yeon

AU - Kil, Ye Chan

AU - Yang, Da Hye

AU - Park, Dal Yong

AU - Jang, Hee Jun

AU - Park, Song Kyu

AU - Jung, Yong Woo

AU - Yoon, Hong Yeol

AU - Kim, Kwangmeyung

AU - Song, Daesub

AU - Yuk, Soon Hong

PY - 2023/1

Y1 - 2023/1

N2 - Phototherapeutic nanoparticles (NPs) were prepared with methylene blue (MB), indocyanine green (ICG), and Solutol through self-assembly. Generation of reactive oxygen species and elevation of temperature were observed that verify the photodynamic/photothermal effects of the NPs. Morphology and size distribution of the NPs were examined by transmittance electron microscopy and dynamic light scattering. The biodistribution of the NPs and their antitumor efficacy were examined using tumor-bearing mice to understand the phototherapeutic effect of the NPs on tumors. To enhance targetability with enhanced therapeutic efficacy, empty NPs (Solutol nanoparticles without MB and ICG) at different concentrations were injected along with the phototherapeutic NPs. Enhanced delivery of the phototherapeutic NPs at the tumor site was examined based on hepatocyte overload.

AB - Phototherapeutic nanoparticles (NPs) were prepared with methylene blue (MB), indocyanine green (ICG), and Solutol through self-assembly. Generation of reactive oxygen species and elevation of temperature were observed that verify the photodynamic/photothermal effects of the NPs. Morphology and size distribution of the NPs were examined by transmittance electron microscopy and dynamic light scattering. The biodistribution of the NPs and their antitumor efficacy were examined using tumor-bearing mice to understand the phototherapeutic effect of the NPs on tumors. To enhance targetability with enhanced therapeutic efficacy, empty NPs (Solutol nanoparticles without MB and ICG) at different concentrations were injected along with the phototherapeutic NPs. Enhanced delivery of the phototherapeutic NPs at the tumor site was examined based on hepatocyte overload.

KW - Hepatocyte overload

KW - Indocyanine green

KW - Methylene blue

KW - Phototheraputic nanoparticles

KW - Solutol

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U2 - 10.1016/j.colsurfb.2022.112959

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AN - SCOPUS:85141273972

SN - 0927-7765

VL - 221

JO - Colloids and Surfaces B: Biointerfaces

JF - Colloids and Surfaces B: Biointerfaces

M1 - 112959

ER -

Enhanced delivery of the phototherapeutic nanoparticles via hepatocyte overload

Abstract

Bibliographical note

Keywords

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