Phototherapeutic nanoparticles (NPs) were prepared with methylene blue (MB), indocyanine green (ICG), and Solutol through self-assembly. Generation of reactive oxygen species and elevation of temperature were observed that verify the photodynamic/photothermal effects of the NPs. Morphology and size distribution of the NPs were examined by transmittance electron microscopy and dynamic light scattering. The biodistribution of the NPs and their antitumor efficacy were examined using tumor-bearing mice to understand the phototherapeutic effect of the NPs on tumors. To enhance targetability with enhanced therapeutic efficacy, empty NPs (Solutol nanoparticles without MB and ICG) at different concentrations were injected along with the phototherapeutic NPs. Enhanced delivery of the phototherapeutic NPs at the tumor site was examined based on hepatocyte overload.
Bibliographical noteFunding Information:
This research was supported by the Basic Science Research Program through the National Research Foundation of Korea ( NRF ) funded by the Ministry of Science, ICT, and Future Planning (NRF- 2021R1A2C2004279 ) and the Key Research Institutes in Universities through the National Research Foundation of Korea funded by the Ministry of Science, ICT, and Future planning (NRF- 2019R1A6A1A03031807 and NRF- 2021M3E5E3080556 )).
© 2022 Elsevier B.V.
- Hepatocyte overload
- Indocyanine green
- Methylene blue
- Phototheraputic nanoparticles