Purpose We investigated the value of early dynamic (ED) PET for the detection and characterization of bladder cancer. Methods Fifty-Two bladder cancer patients were prospectively enrolled. The study protocol was composed of ED, whole-body (WB, 60 minutes after injection), and additional delayed (AD, 120 minutes after injection) PET acquisition. Early dynamic PET was acquired for 10 minutes and reconstructed as 5 frames at 2-minute intervals. A focal radiotracer accumulation confined to the bladder wall was considered as PET positive and referred for further quantitative measurement. SUVmax on ED (1fSUVmax, 2fSUVmax, 3fSUVmax, 4fSUVmax, and 5fSUVmax for 5 frames), WB (WBSUVmax), and AD PET (ADSUVmax) were measured. PET results were correlated with bladder cancer pathology variables. Results The sensitivities of ED, WB, and AD PET for bladder cancer were 84.6%, 57.7%, and 61.2%, respectively. The sensitivity of ED PET was significantly higher than that of WB (P = 0.002) and AD PET (P = 0.008). On ED PET, 2fSUVmax was significantly correlated with muscle invasiveness, histological grade, and pathological tumor size (P = 0.018, P = 0.030, and P = 0.030). On WB and AD PET, only pathological tumor size showed significant positive correlation with WBSUVmax and ADSUVmax (P = 0.043 and P = 0.007). Conclusions Early dynamic PET can help to detect and characterize bladder cancer.
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Received for publication May 17, 2017; revision accepted June 30, 2017. From the *Department of Nuclear Medicine, †Clinical Research Institute, and ‡Department of Urology, College of Medicine, Ewha Womans University, Seoul, Republic of Korea. Conflicts of interest and sources of funding: This work was supported by the National Research Foundation (2015R1C1A2A01054113 to H.-J.Y., 2015R1C1A1A02037051 and 2012M3A9B6055379 to B.S.K.) of South Korea. Correspondence to: Bom Sahn Kim, MD, PhD, Department of Nuclear Medicine, Ewha Womans University College of Medicine, 911-1 Mok-Dong, Yangchun-Ku, Seoul 158-710, Korea. E-mail: firstname.lastname@example.org. kr; or Hai-Jeon Yoon, MD, Department of Nuclear Medicine, Ewha Womans University College of Medicine, 911-1 Mok-Dong, Yangchun-Ku, Seoul 158-710, Korea. E-mail: email@example.com. Copyright © 2017 Wolters Kluwer Health, Inc. All rights reserved. ISSN: 0363-9762/17/4210–0749 DOI: 10.1097/RLU.0000000000001780
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- bladder cancer
- early dynamic PET/CT
- tumor blood flow
- urine activity