Enhanced Application of 18F-FDG PET/CT in Bladder Cancer by Adding Early Dynamic Acquisition to a Standard Delayed PET Protocol

Hai Jeon Yoon; Jang Yoo; Yemi Kim; Dong Hyeon Lee; Bom Sahn Kim

doi:10.1097/RLU.0000000000001780

Enhanced Application of ¹⁸F-FDG PET/CT in Bladder Cancer by Adding Early Dynamic Acquisition to a Standard Delayed PET Protocol

Hai Jeon Yoon, Jang Yoo, Yemi Kim, Dong Hyeon Lee, Bom Sahn Kim

Research output: Contribution to journal › Article › peer-review

11 Scopus citations

Abstract

Purpose We investigated the value of early dynamic (ED) PET for the detection and characterization of bladder cancer. Methods Fifty-Two bladder cancer patients were prospectively enrolled. The study protocol was composed of ED, whole-body (WB, 60 minutes after injection), and additional delayed (AD, 120 minutes after injection) PET acquisition. Early dynamic PET was acquired for 10 minutes and reconstructed as 5 frames at 2-minute intervals. A focal radiotracer accumulation confined to the bladder wall was considered as PET positive and referred for further quantitative measurement. SUVmax on ED (^1fSUVmax, ^2fSUVmax, ^3fSUVmax, ^4fSUVmax, and ^5fSUVmax for 5 frames), WB (^WBSUVmax), and AD PET (^ADSUVmax) were measured. PET results were correlated with bladder cancer pathology variables. Results The sensitivities of ED, WB, and AD PET for bladder cancer were 84.6%, 57.7%, and 61.2%, respectively. The sensitivity of ED PET was significantly higher than that of WB (P = 0.002) and AD PET (P = 0.008). On ED PET, ^2fSUVmax was significantly correlated with muscle invasiveness, histological grade, and pathological tumor size (P = 0.018, P = 0.030, and P = 0.030). On WB and AD PET, only pathological tumor size showed significant positive correlation with ^WBSUVmax and ^ADSUVmax (P = 0.043 and P = 0.007). Conclusions Early dynamic PET can help to detect and characterize bladder cancer.

Original language	English
Pages (from-to)	749-755
Number of pages	7
Journal	Clinical Nuclear Medicine
Volume	42
Issue number	10
DOIs	https://doi.org/10.1097/RLU.0000000000001780
State	Published - 1 Oct 2017

Bibliographical note

Funding Information:
Received for publication May 17, 2017; revision accepted June 30, 2017. From the *Department of Nuclear Medicine, †Clinical Research Institute, and ‡Department of Urology, College of Medicine, Ewha Womans University, Seoul, Republic of Korea. Conflicts of interest and sources of funding: This work was supported by the National Research Foundation (2015R1C1A2A01054113 to H.-J.Y., 2015R1C1A1A02037051 and 2012M3A9B6055379 to B.S.K.) of South Korea. Correspondence to: Bom Sahn Kim, MD, PhD, Department of Nuclear Medicine, Ewha Womans University College of Medicine, 911-1 Mok-Dong, Yangchun-Ku, Seoul 158-710, Korea. E-mail: kbomsahn@ewha.ac. kr; or Hai-Jeon Yoon, MD, Department of Nuclear Medicine, Ewha Womans University College of Medicine, 911-1 Mok-Dong, Yangchun-Ku, Seoul 158-710, Korea. E-mail: haijeon.yoon@gmail.com. Copyright © 2017 Wolters Kluwer Health, Inc. All rights reserved. ISSN: 0363-9762/17/4210–0749 DOI: 10.1097/RLU.0000000000001780

Publisher Copyright:
© Wolters Kluwer Health, Inc. All rights reserved.

Keywords

F-FDG
bladder cancer
early dynamic PET/CT
tumor blood flow
urine activity

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1097/RLU.0000000000001780

Cite this

@article{7454f7c62fd14b37bfb9f1a68717ff08,

title = "Enhanced Application of 18F-FDG PET/CT in Bladder Cancer by Adding Early Dynamic Acquisition to a Standard Delayed PET Protocol",

abstract = "Purpose We investigated the value of early dynamic (ED) PET for the detection and characterization of bladder cancer. Methods Fifty-Two bladder cancer patients were prospectively enrolled. The study protocol was composed of ED, whole-body (WB, 60 minutes after injection), and additional delayed (AD, 120 minutes after injection) PET acquisition. Early dynamic PET was acquired for 10 minutes and reconstructed as 5 frames at 2-minute intervals. A focal radiotracer accumulation confined to the bladder wall was considered as PET positive and referred for further quantitative measurement. SUVmax on ED (1fSUVmax, 2fSUVmax, 3fSUVmax, 4fSUVmax, and 5fSUVmax for 5 frames), WB (WBSUVmax), and AD PET (ADSUVmax) were measured. PET results were correlated with bladder cancer pathology variables. Results The sensitivities of ED, WB, and AD PET for bladder cancer were 84.6%, 57.7%, and 61.2%, respectively. The sensitivity of ED PET was significantly higher than that of WB (P = 0.002) and AD PET (P = 0.008). On ED PET, 2fSUVmax was significantly correlated with muscle invasiveness, histological grade, and pathological tumor size (P = 0.018, P = 0.030, and P = 0.030). On WB and AD PET, only pathological tumor size showed significant positive correlation with WBSUVmax and ADSUVmax (P = 0.043 and P = 0.007). Conclusions Early dynamic PET can help to detect and characterize bladder cancer.",

keywords = "F-FDG, bladder cancer, early dynamic PET/CT, tumor blood flow, urine activity",

author = "Yoon, {Hai Jeon} and Jang Yoo and Yemi Kim and Lee, {Dong Hyeon} and Kim, {Bom Sahn}",

note = "Funding Information: Received for publication May 17, 2017; revision accepted June 30, 2017. From the *Department of Nuclear Medicine, †Clinical Research Institute, and ‡Department of Urology, College of Medicine, Ewha Womans University, Seoul, Republic of Korea. Conflicts of interest and sources of funding: This work was supported by the National Research Foundation (2015R1C1A2A01054113 to H.-J.Y., 2015R1C1A1A02037051 and 2012M3A9B6055379 to B.S.K.) of South Korea. Correspondence to: Bom Sahn Kim, MD, PhD, Department of Nuclear Medicine, Ewha Womans University College of Medicine, 911-1 Mok-Dong, Yangchun-Ku, Seoul 158-710, Korea. E-mail: kbomsahn@ewha.ac. kr; or Hai-Jeon Yoon, MD, Department of Nuclear Medicine, Ewha Womans University College of Medicine, 911-1 Mok-Dong, Yangchun-Ku, Seoul 158-710, Korea. E-mail: haijeon.yoon@gmail.com. Copyright {\textcopyright} 2017 Wolters Kluwer Health, Inc. All rights reserved. ISSN: 0363-9762/17/4210–0749 DOI: 10.1097/RLU.0000000000001780 Publisher Copyright: {\textcopyright} Wolters Kluwer Health, Inc. All rights reserved.",

year = "2017",

month = oct,

day = "1",

doi = "10.1097/RLU.0000000000001780",

language = "English",

volume = "42",

pages = "749--755",

journal = "Clinical Nuclear Medicine",

issn = "0363-9762",

publisher = "Lippincott Williams and Wilkins Ltd.",

number = "10",

}

TY - JOUR

T1 - Enhanced Application of 18F-FDG PET/CT in Bladder Cancer by Adding Early Dynamic Acquisition to a Standard Delayed PET Protocol

AU - Yoon, Hai Jeon

AU - Yoo, Jang

AU - Kim, Yemi

AU - Lee, Dong Hyeon

AU - Kim, Bom Sahn

N1 - Funding Information: Received for publication May 17, 2017; revision accepted June 30, 2017. From the *Department of Nuclear Medicine, †Clinical Research Institute, and ‡Department of Urology, College of Medicine, Ewha Womans University, Seoul, Republic of Korea. Conflicts of interest and sources of funding: This work was supported by the National Research Foundation (2015R1C1A2A01054113 to H.-J.Y., 2015R1C1A1A02037051 and 2012M3A9B6055379 to B.S.K.) of South Korea. Correspondence to: Bom Sahn Kim, MD, PhD, Department of Nuclear Medicine, Ewha Womans University College of Medicine, 911-1 Mok-Dong, Yangchun-Ku, Seoul 158-710, Korea. E-mail: kbomsahn@ewha.ac. kr; or Hai-Jeon Yoon, MD, Department of Nuclear Medicine, Ewha Womans University College of Medicine, 911-1 Mok-Dong, Yangchun-Ku, Seoul 158-710, Korea. E-mail: haijeon.yoon@gmail.com. Copyright © 2017 Wolters Kluwer Health, Inc. All rights reserved. ISSN: 0363-9762/17/4210–0749 DOI: 10.1097/RLU.0000000000001780 Publisher Copyright: © Wolters Kluwer Health, Inc. All rights reserved.

PY - 2017/10/1

Y1 - 2017/10/1

N2 - Purpose We investigated the value of early dynamic (ED) PET for the detection and characterization of bladder cancer. Methods Fifty-Two bladder cancer patients were prospectively enrolled. The study protocol was composed of ED, whole-body (WB, 60 minutes after injection), and additional delayed (AD, 120 minutes after injection) PET acquisition. Early dynamic PET was acquired for 10 minutes and reconstructed as 5 frames at 2-minute intervals. A focal radiotracer accumulation confined to the bladder wall was considered as PET positive and referred for further quantitative measurement. SUVmax on ED (1fSUVmax, 2fSUVmax, 3fSUVmax, 4fSUVmax, and 5fSUVmax for 5 frames), WB (WBSUVmax), and AD PET (ADSUVmax) were measured. PET results were correlated with bladder cancer pathology variables. Results The sensitivities of ED, WB, and AD PET for bladder cancer were 84.6%, 57.7%, and 61.2%, respectively. The sensitivity of ED PET was significantly higher than that of WB (P = 0.002) and AD PET (P = 0.008). On ED PET, 2fSUVmax was significantly correlated with muscle invasiveness, histological grade, and pathological tumor size (P = 0.018, P = 0.030, and P = 0.030). On WB and AD PET, only pathological tumor size showed significant positive correlation with WBSUVmax and ADSUVmax (P = 0.043 and P = 0.007). Conclusions Early dynamic PET can help to detect and characterize bladder cancer.

AB - Purpose We investigated the value of early dynamic (ED) PET for the detection and characterization of bladder cancer. Methods Fifty-Two bladder cancer patients were prospectively enrolled. The study protocol was composed of ED, whole-body (WB, 60 minutes after injection), and additional delayed (AD, 120 minutes after injection) PET acquisition. Early dynamic PET was acquired for 10 minutes and reconstructed as 5 frames at 2-minute intervals. A focal radiotracer accumulation confined to the bladder wall was considered as PET positive and referred for further quantitative measurement. SUVmax on ED (1fSUVmax, 2fSUVmax, 3fSUVmax, 4fSUVmax, and 5fSUVmax for 5 frames), WB (WBSUVmax), and AD PET (ADSUVmax) were measured. PET results were correlated with bladder cancer pathology variables. Results The sensitivities of ED, WB, and AD PET for bladder cancer were 84.6%, 57.7%, and 61.2%, respectively. The sensitivity of ED PET was significantly higher than that of WB (P = 0.002) and AD PET (P = 0.008). On ED PET, 2fSUVmax was significantly correlated with muscle invasiveness, histological grade, and pathological tumor size (P = 0.018, P = 0.030, and P = 0.030). On WB and AD PET, only pathological tumor size showed significant positive correlation with WBSUVmax and ADSUVmax (P = 0.043 and P = 0.007). Conclusions Early dynamic PET can help to detect and characterize bladder cancer.

KW - F-FDG

KW - bladder cancer

KW - early dynamic PET/CT

KW - tumor blood flow

KW - urine activity

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U2 - 10.1097/RLU.0000000000001780

DO - 10.1097/RLU.0000000000001780

M3 - Article

C2 - 28759520

AN - SCOPUS:85032342262

SN - 0363-9762

VL - 42

SP - 749

EP - 755

JO - Clinical Nuclear Medicine

JF - Clinical Nuclear Medicine

IS - 10

ER -