Engineered microbial biosensors based on bacterial two-component systems as synthetic biotechnology platforms in bioremediation and biorefinery

Sambandam Ravikumar, Mary Grace Baylon, Si Jae Park, Jong il Choi

Research output: Contribution to journalReview articlepeer-review

30 Scopus citations

Abstract

Two-component regulatory systems (TCRSs) mediate cellular response by coupling sensing and regulatory mechanisms. TCRSs are comprised of a histidine kinase (HK), which serves as a sensor, and a response regulator, which regulates expression of the effector gene after being phosphorylated by HK. Using these attributes, bacterial TCRSs can be engineered to design microbial systems for different applications. This review focuses on the current advances in TCRS-based biosensors and on the design of microbial systems for bioremediation and their potential application in biorefinery.

Original languageEnglish
Article number62
JournalMicrobial Cell Factories
Volume16
Issue number1
DOIs
StatePublished - 14 Apr 2017

Keywords

  • Biorefinery
  • Bioremediation
  • Biosensor
  • Genetic circuit
  • Two-component regulatory system

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