Endoscopic ultrasound-guided fine needle aspiration (EUS-FNA) contributes to a triple-negative test in preoperative screening of pancreatic cysts

Roseann I. Wu, Won Jae Yoon, William R. Brugge, Mari Mino-Kenudson, Martha B. Pitman

Research output: Contribution to journalArticlepeer-review

14 Scopus citations


BACKGROUND: Endoscopic ultrasound-guided fine-needle aspiration (EUS-FNA) of pancreatic cysts obtains cyst fluid for cytologic and biochemical analysis, which may determine whether the cyst is mucinous and malignant, contributing to patient management. Despite this added value, EUS-FNA remains controversial in the preoperative assessment of pancreatic cysts. The objective of this study was to assess the utility of EUS-FNA in a cohort of small pancreatic cysts that were benign on imaging studies. METHODS: All pancreatic cysts that underwent initial EUS-FNA in 2006 and 2007 were retrospectively analyzed. Ninety-two patients with pancreatic cysts met the inclusion criteria. Patients who had high-risk or worrisome features on imaging studies were excluded. Cytology, histology, and cyst fluid analysis data were collected. The main outcome measurements were radiologic and clinical follow-up as well as cytopathologic and histologic results. RESULTS: EUS-FNA supported a diagnosis of a mucinous cyst in 38 of 92 patients (41%) by carcinoembryonic antigen (CEA) measurement and/or cytology. Cytology demonstrated an absence of high-grade atypia (HGA) in 89 of 92 patients (97%). The mean follow-up was 4.4 years (range, 0-7.7 years), during which 6 cysts were surgically resected and 16 cysts were resampled by at least 1 subsequent EUS-FNA. The overall negative predictive value of cytologic examination for HGA was 99%. CONCLUSIONS: EUS-FNA is a screening test that contributes to a triple-negative test for pancreatic cysts-no high-risk stigmata, no worrisome features, and no HGA on cytology-providing a negative predictive value of 99% for conservative management.

Original languageEnglish
Pages (from-to)412-419
Number of pages8
JournalCancer Cytopathology
Issue number6
StatePublished - Jun 2014


  • Carcinoembryonic antigen
  • Cytopathology
  • Endoscopic ultrasound-guided fine-needle aspiration
  • Pancreatic cyst
  • Pancreatic neoplasms


Dive into the research topics of 'Endoscopic ultrasound-guided fine needle aspiration (EUS-FNA) contributes to a triple-negative test in preoperative screening of pancreatic cysts'. Together they form a unique fingerprint.

Cite this