Endoscopic Evaluation of Bile Duct Strictures

Won Jae Yoon, William R. Brugge

Research output: Contribution to journalReview articlepeer-review

26 Scopus citations


Differentiating between malignant and benign bile duct strictures is often challenging. Endoscopic retrograde cholangiopancreatography with brush cytology and/or endobiliary forceps biopsy is routinely performed. Advanced cytologic methods such as fluorescence in situ hybridization or digital image analysis increases the sensitivity of cytology. Endoscopic ultrasonography enables detailed examination of tissues surrounding the bile duct stricture and offers the advantage of fine-needle aspiration. Intraductal ultrasonography enables detailed evaluation of bile duct wall layers, and cholangioscopy offers direct visualization of the bile duct lesions. Novel techniques of probe-based confocal laser endomicroscopy and optical coherence tomography have introduced the era of in vivo histology.

Original languageEnglish
Pages (from-to)277-293
Number of pages17
JournalGastrointestinal Endoscopy Clinics of North America
Issue number2
StatePublished - Apr 2013


  • Bile duct stricture
  • Cholangioscopy
  • Endoscopic retrograde cholangiopancreatography
  • Endoscopic ultrasonography
  • Fluorescence in situ hybridization
  • Intraductal ultrasonography
  • Optical coherence tomography
  • Probe-based confocal laser endomicroscopy


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