@article{d058570599b74eecaa55c8c5939d0c10,
title = "Endoplasmic Reticulum-Targeted Ratiometric N-Heterocyclic Carbene Borane Probe for Two-Photon Microscopic Imaging of Hypochlorous Acid",
abstract = "The naphthoimidazolium borane 4 is shown to be a selective probe for HOCl over other reactive oxygen species. Unlike other boronate-reactive oxygen species (ROS) fluorogenic probes that are oxidized by HOCl through a nucleophilic borono-Dakin oxidation mechanism, probe 4 is distinguished by its electrophilic oxidation mechanism involving B-H bond cleavage. Two-photon microscopy experiments in living cells and tissues with the probe 4 demonstrate the monitoring of endogenous HOCl generation and changes in HOCl concentrations generated in the endoplasmic reticulum during oxidative stress situations.",
author = "Pak, {Yen Leng} and Park, {Sang Jun} and Gyeongok Song and Yubin Yim and Hyuk Kang and Kim, {Hwan Myung} and Jean Bouffard and Juyoung Yoon",
note = "Funding Information: We thank the National Research Foundation of Korea for the financial support (2012R1A3A2048814 to J.Y., 2016-R1E1A1A02920873 to H.M.K., and 2018R1D1A1B07043568 to J.B.). We also thank the Western Seoul (LC−MS) and Daegu (FAB) branches of the Korea Basic Science Institute for mass spectrometric data. Publisher Copyright: {\textcopyright} 2018 American Chemical Society.",
year = "2018",
month = nov,
day = "6",
doi = "10.1021/acs.analchem.8b03565",
language = "English",
volume = "90",
pages = "12937--12943",
journal = "Analytical Chemistry",
issn = "0003-2700",
publisher = "American Chemical Society",
number = "21",
}