Enantioselective Synthesis of a Novel Thiazoline Core as a Potent Peroxisome Proliferator-Activated Receptor δ Agonist

Su Jeong Lee, Mallesham Samala, Seo Yeon Woo, Dongyup Hahn, Dayoung Kim, Tara Man Kadayat, Kyungjin Jung, Jina Kim, Dong Su Kim, Sugyeong Kwon, Shinae Kim, Kyung Hee Kim, Sang Jip Nam, Sung Jin Cho, Jungwook Chin

Research output: Contribution to journalArticlepeer-review

3 Scopus citations

Abstract

The convergent and enantioselective synthesis of a highly potent human peroxisome proliferator-activated receptor delta agonist is presented. More specifically, the thiazoline structure, which constitutes the biosynthetically distinctive core structure of pulicatin (a secondary metabolite of symbiotic bacteria), was synthesized from a commercially available and inexpensive chiral pool of l-threonine.

Original languageEnglish
Pages (from-to)1970-1976
Number of pages7
JournalACS Omega
Volume3
Issue number2
DOIs
StatePublished - 28 Feb 2018

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