Enantioselective Synthesis of a Novel Thiazoline Core as a Potent Peroxisome Proliferator-Activated Receptor δ Agonist

Su Jeong Lee; Mallesham Samala; Seo Yeon Woo; Dongyup Hahn; Dayoung Kim; Tara Man Kadayat; Kyungjin Jung; Jina Kim; Dong Su Kim; Sugyeong Kwon; Shinae Kim; Kyung Hee Kim; Sang Jip Nam; Sung Jin Cho; Jungwook Chin

doi:10.1021/acsomega.7b01689

Enantioselective Synthesis of a Novel Thiazoline Core as a Potent Peroxisome Proliferator-Activated Receptor δ Agonist

Su Jeong Lee, Mallesham Samala, Seo Yeon Woo, Dongyup Hahn, Dayoung Kim, Tara Man Kadayat, Kyungjin Jung, Jina Kim, Dong Su Kim, Sugyeong Kwon, Shinae Kim, Kyung Hee Kim, Sang Jip Nam, Sung Jin Cho, Jungwook Chin

Department of Chemistry & Nanoscience

Research output: Contribution to journal › Article › peer-review

7 Scopus citations

Abstract

The convergent and enantioselective synthesis of a highly potent human peroxisome proliferator-activated receptor delta agonist is presented. More specifically, the thiazoline structure, which constitutes the biosynthetically distinctive core structure of pulicatin (a secondary metabolite of symbiotic bacteria), was synthesized from a commercially available and inexpensive chiral pool of l-threonine.

Original language	English
Pages (from-to)	1970-1976
Number of pages	7
Journal	ACS Omega
Volume	3
Issue number	2
DOIs	https://doi.org/10.1021/acsomega.7b01689
State	Published - 28 Feb 2018

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© 2018 American Chemical Society.

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title = "Enantioselective Synthesis of a Novel Thiazoline Core as a Potent Peroxisome Proliferator-Activated Receptor δ Agonist",

abstract = "The convergent and enantioselective synthesis of a highly potent human peroxisome proliferator-activated receptor delta agonist is presented. More specifically, the thiazoline structure, which constitutes the biosynthetically distinctive core structure of pulicatin (a secondary metabolite of symbiotic bacteria), was synthesized from a commercially available and inexpensive chiral pool of l-threonine.",

author = "Lee, {Su Jeong} and Mallesham Samala and Woo, {Seo Yeon} and Dongyup Hahn and Dayoung Kim and Kadayat, {Tara Man} and Kyungjin Jung and Jina Kim and Kim, {Dong Su} and Sugyeong Kwon and Shinae Kim and Kim, {Kyung Hee} and Nam, {Sang Jip} and Cho, {Sung Jin} and Jungwook Chin",

note = "Publisher Copyright: {\textcopyright} 2018 American Chemical Society.",

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doi = "10.1021/acsomega.7b01689",

language = "English",

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T1 - Enantioselective Synthesis of a Novel Thiazoline Core as a Potent Peroxisome Proliferator-Activated Receptor δ Agonist

AU - Lee, Su Jeong

AU - Samala, Mallesham

AU - Woo, Seo Yeon

AU - Hahn, Dongyup

AU - Kim, Dayoung

AU - Kadayat, Tara Man

AU - Jung, Kyungjin

AU - Kim, Jina

AU - Kim, Dong Su

AU - Kwon, Sugyeong

AU - Kim, Shinae

AU - Kim, Kyung Hee

AU - Nam, Sang Jip

AU - Cho, Sung Jin

AU - Chin, Jungwook

PY - 2018/2/28

Y1 - 2018/2/28

N2 - The convergent and enantioselective synthesis of a highly potent human peroxisome proliferator-activated receptor delta agonist is presented. More specifically, the thiazoline structure, which constitutes the biosynthetically distinctive core structure of pulicatin (a secondary metabolite of symbiotic bacteria), was synthesized from a commercially available and inexpensive chiral pool of l-threonine.

AB - The convergent and enantioselective synthesis of a highly potent human peroxisome proliferator-activated receptor delta agonist is presented. More specifically, the thiazoline structure, which constitutes the biosynthetically distinctive core structure of pulicatin (a secondary metabolite of symbiotic bacteria), was synthesized from a commercially available and inexpensive chiral pool of l-threonine.

UR - http://www.scopus.com/inward/record.url?scp=85052898157&partnerID=8YFLogxK

U2 - 10.1021/acsomega.7b01689

DO - 10.1021/acsomega.7b01689

M3 - Article

AN - SCOPUS:85052898157

SN - 2470-1343

VL - 3

SP - 1970

EP - 1976

JO - ACS Omega

JF - ACS Omega

IS - 2

ER -

Enantioselective Synthesis of a Novel Thiazoline Core as a Potent Peroxisome Proliferator-Activated Receptor δ Agonist

Abstract

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