Abstract
Novel binol receptor with pyrrole-2-carboxamide moiety and its analogues have been designed, synthesized, and used to enantioselectively recognize 1,2-aminoalcohols via multiple hydrogen bonding. The pyrrole-based binol receptor showed the highest enantioselectivity among the four receptors as determined by the 1H NMR. The DFT calculation strongly supports complementary hydrogen bonding between alcoholic -OH and pyrrolyl groups.
Original language | English |
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Pages (from-to) | 666-671 |
Number of pages | 6 |
Journal | Tetrahedron |
Volume | 65 |
Issue number | 3 |
DOIs | |
State | Published - 17 Jan 2009 |
Keywords
- Aminoalcohol
- Enantioselective recognition
- Pyrrole-2-carboxamide