Enabling techniques in the search for new antibiotics: Combinatorial biosynthesis of sugar-containing antibiotics

Je Won Park; Sang Jip Nam; Yeo Joon Yoon

doi:10.1016/j.bcp.2016.10.009

Enabling techniques in the search for new antibiotics: Combinatorial biosynthesis of sugar-containing antibiotics

Je Won Park, Sang Jip Nam, Yeo Joon Yoon

Department of Chemistry & Nanoscience

Research output: Contribution to journal › Review article › peer-review

15 Scopus citations

Abstract

Nature has a talent for inventing a vast number of natural products, including hybrids generated by blending different scaffolds, resulting in a myriad of bioactive chemical entities. Herein, we review the highlights and recent trends (2010–2016) in the combinatorial biosynthesis of sugar-containing antibiotics where nature's structural diversification capabilities are exploited to enable the creation of new anti-infective and anti-proliferative drugs. In this review, we describe the modern combinatorial biosynthetic approaches for polyketide synthase-derived complex and aromatic polyketides, non-ribosomal peptide synthetase-directed lipo-/glycopeptides, aminoglycosides, nucleoside antibiotics, and alkaloids, along with their therapeutic potential. Finally, we present the feasible nexus between combinatorial biosynthesis, systems biology, and synthetic biology as a toolbox to provide new antibiotics that will be indispensable in the post-antibiotic era.

Original language	English
Pages (from-to)	56-73
Number of pages	18
Journal	Biochemical Pharmacology
Volume	134
DOIs	https://doi.org/10.1016/j.bcp.2016.10.009
State	Published - 15 Jun 2017

Bibliographical note

Funding Information:
We thank Dr. Kris Rathwell for critical reading this manuscript. This work was supported by the National Research Foundation of Korea grant (2016R1A2A1A05005078, 2015R1A2A2A01002524 [J.W.P.]) funded by the Ministry of Science, ICT and Future Planning (MISP), the Intelligent Synthetic Biology Center of the Global Frontier Project funded by MISP (20110031961), Advanced Production Technology Development Program and High Value-added Food Technology Development Program, Ministry of Agriculture, Food and Rural Affairs, Republic of Korea. J.W.P. also thanks to the grant (PJ011066) funded by the Next-Generation BioGreen21 program, Rural Development Administration.

Publisher Copyright:
© 2016 Elsevier Inc.

Keywords

Anti-infective and anti-proliferative
Combinatorial biosynthesis
Sugar-containing antibiotics

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10.1016/j.bcp.2016.10.009

Cite this

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title = "Enabling techniques in the search for new antibiotics: Combinatorial biosynthesis of sugar-containing antibiotics",

abstract = "Nature has a talent for inventing a vast number of natural products, including hybrids generated by blending different scaffolds, resulting in a myriad of bioactive chemical entities. Herein, we review the highlights and recent trends (2010–2016) in the combinatorial biosynthesis of sugar-containing antibiotics where nature's structural diversification capabilities are exploited to enable the creation of new anti-infective and anti-proliferative drugs. In this review, we describe the modern combinatorial biosynthetic approaches for polyketide synthase-derived complex and aromatic polyketides, non-ribosomal peptide synthetase-directed lipo-/glycopeptides, aminoglycosides, nucleoside antibiotics, and alkaloids, along with their therapeutic potential. Finally, we present the feasible nexus between combinatorial biosynthesis, systems biology, and synthetic biology as a toolbox to provide new antibiotics that will be indispensable in the post-antibiotic era.",

keywords = "Anti-infective and anti-proliferative, Combinatorial biosynthesis, Sugar-containing antibiotics",

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AB - Nature has a talent for inventing a vast number of natural products, including hybrids generated by blending different scaffolds, resulting in a myriad of bioactive chemical entities. Herein, we review the highlights and recent trends (2010–2016) in the combinatorial biosynthesis of sugar-containing antibiotics where nature's structural diversification capabilities are exploited to enable the creation of new anti-infective and anti-proliferative drugs. In this review, we describe the modern combinatorial biosynthetic approaches for polyketide synthase-derived complex and aromatic polyketides, non-ribosomal peptide synthetase-directed lipo-/glycopeptides, aminoglycosides, nucleoside antibiotics, and alkaloids, along with their therapeutic potential. Finally, we present the feasible nexus between combinatorial biosynthesis, systems biology, and synthetic biology as a toolbox to provide new antibiotics that will be indispensable in the post-antibiotic era.

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Enabling techniques in the search for new antibiotics: Combinatorial biosynthesis of sugar-containing antibiotics

Abstract

Bibliographical note

Keywords

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