Abstract
Among many treatment options to prevent cancer progression, cancer immunotherapy has become a powerful clinical strategy due to its favorable clinical outcomes. The number of clinical trials in immune checkpoint blockade (ICB) therapy and chimeric antigen receptor (CAR)-T cell therapy has been remarkably increasing in recent years. However, the currently available options for these treatments pose significant challenges related to immune-related adverse effects and limited therapeutic efficacy. Excellent delivery technologies by leveraging biomaterials to mitigate these limitations could potentially advance current cancer immunotherapies for a wide range of applications. In this review, we analyze various strategies of biomaterial-assisted cancer immunotherapy for localized, targeted, and combined treatments and then summarize the promises and challenges for integrating biomaterial-based delivery technologies into cancer immunotherapy.
| Original language | English |
|---|---|
| Pages (from-to) | 227-240 |
| Number of pages | 14 |
| Journal | Korean Journal of Chemical Engineering |
| Volume | 39 |
| Issue number | 2 |
| DOIs | |
| State | Published - Feb 2022 |
Bibliographical note
Publisher Copyright:© 2022, The Korean Institute of Chemical Engineers.
Keywords
- Biomaterials
- Cancer Immunotherapy
- Combination Therapy
- Immuno-engineering
- Localized Delivery