Emergence of serotype 10A-ST11189 among pediatric invasive pneumococcal diseases, South Korea, 2014–2019

Ki Wook Yun; Kyuyol Rhie; Jin Han Kang; Kyung Hyo Kim; Jong Gyun Ahn; Yae Jean Kim; Byung Wook Eun; Sung Hee Oh; Hye Kyung Cho; Young Jin Hong; Nam Hee Kim; Yun Kyung Kim; Hyunju Lee; Taekjin Lee; Hwang Min Kim; Eun Young Cho; Chun Soo Kim; Su Eun Park; Chi Eun Oh; Dae Sun Jo; Eun Song Song; Jina Lee; Jae Hong Choi; Joon Kee Lee; Hoan Jong Lee; Eun Hwa Choi

doi:10.1016/j.vaccine.2021.08.072

Emergence of serotype 10A-ST11189 among pediatric invasive pneumococcal diseases, South Korea, 2014–2019

Ki Wook Yun, Kyuyol Rhie, Jin Han Kang, Kyung Hyo Kim, Jong Gyun Ahn, Yae Jean Kim, Byung Wook Eun, Sung Hee Oh, Hye Kyung Cho, Young Jin Hong, Nam Hee Kim, Yun Kyung Kim, Hyunju Lee, Taekjin Lee, Hwang Min Kim, Eun Young Cho, Chun Soo Kim, Su Eun Park, Chi Eun Oh, Dae Sun JoEun Song Song, Jina Lee, Jae Hong Choi, Joon Kee Lee, Hoan Jong Lee, Eun Hwa Choi

Department of Pediatrics

Research output: Contribution to journal › Article › peer-review

5 Scopus citations

Abstract

Replacement with nonvaccine serotypes (NVTs) among invasive pneumococcal diseases (IPDs) after the introduction of extended-valency pneumococcal conjugate vaccines varies in predominant serotypes across countries. This study analyzed changes in serotype distribution through serotyping, multilocus sequence typing, and antimicrobial susceptibility testing of 168 pediatric IPD isolates obtained from a multihospital-based surveillance system during 2014–2019 in South Korea. Vaccine serotypes (VTs) accounted for 16.1% (19A, 10.1%; 6A, 1.8%; and 19F 1.8%), 82.1% were NVTs (10A, 23.8%; 15A, 8.3%; 12F, 6.5%; 15C, 6.5%; and 15B, 6.0%), and three (1.8%) were nontypeable. Serotype 10A was the most common serotype, with a significant increase from 11.5% in 2014 to 33.3% in 2019 (p < 0.05 for the trend). Other NVTs decreased from 70.4% to 41.7% between 2015 and 2019, most notably in serotype 12F (from 14.8% to 0%). Almost all (95.0%) serotype 10A isolates were ST11189, which were multidrug resistant.

Original language	English
Pages (from-to)	5787-5793
Number of pages	7
Journal	Vaccine
Volume	39
Issue number	40
DOIs	https://doi.org/10.1016/j.vaccine.2021.08.072
State	Published - 24 Sep 2021

Bibliographical note

Publisher Copyright:
© 2021 Elsevier Ltd

Keywords

Children
Genotype
Serotype
Streptococcus pneumoniae

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10.1016/j.vaccine.2021.08.072

Cite this

Yun, K. W., Rhie, K., Kang, J. H., Kim, K. H., Ahn, J. G., Kim, Y. J., Eun, B. W., Oh, S. H., Cho, H. K., Hong, Y. J., Kim, N. H., Kim, Y. K., Lee, H., Lee, T., Kim, H. M., Cho, E. Y., Kim, C. S., Park, S. E., Oh, C. E., ... Choi, E. H. (2021). Emergence of serotype 10A-ST11189 among pediatric invasive pneumococcal diseases, South Korea, 2014–2019. Vaccine, 39(40), 5787-5793. https://doi.org/10.1016/j.vaccine.2021.08.072

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title = "Emergence of serotype 10A-ST11189 among pediatric invasive pneumococcal diseases, South Korea, 2014–2019",

abstract = "Replacement with nonvaccine serotypes (NVTs) among invasive pneumococcal diseases (IPDs) after the introduction of extended-valency pneumococcal conjugate vaccines varies in predominant serotypes across countries. This study analyzed changes in serotype distribution through serotyping, multilocus sequence typing, and antimicrobial susceptibility testing of 168 pediatric IPD isolates obtained from a multihospital-based surveillance system during 2014–2019 in South Korea. Vaccine serotypes (VTs) accounted for 16.1% (19A, 10.1%; 6A, 1.8%; and 19F 1.8%), 82.1% were NVTs (10A, 23.8%; 15A, 8.3%; 12F, 6.5%; 15C, 6.5%; and 15B, 6.0%), and three (1.8%) were nontypeable. Serotype 10A was the most common serotype, with a significant increase from 11.5% in 2014 to 33.3% in 2019 (p < 0.05 for the trend). Other NVTs decreased from 70.4% to 41.7% between 2015 and 2019, most notably in serotype 12F (from 14.8% to 0%). Almost all (95.0%) serotype 10A isolates were ST11189, which were multidrug resistant.",

keywords = "Children, Genotype, Serotype, Streptococcus pneumoniae",

author = "Yun, {Ki Wook} and Kyuyol Rhie and Kang, {Jin Han} and Kim, {Kyung Hyo} and Ahn, {Jong Gyun} and Kim, {Yae Jean} and Eun, {Byung Wook} and Oh, {Sung Hee} and Cho, {Hye Kyung} and Hong, {Young Jin} and Kim, {Nam Hee} and Kim, {Yun Kyung} and Hyunju Lee and Taekjin Lee and Kim, {Hwang Min} and Cho, {Eun Young} and Kim, {Chun Soo} and Park, {Su Eun} and Oh, {Chi Eun} and Jo, {Dae Sun} and Song, {Eun Song} and Jina Lee and Choi, {Jae Hong} and Lee, {Joon Kee} and Lee, {Hoan Jong} and Choi, {Eun Hwa}",

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year = "2021",

month = sep,

day = "24",

doi = "10.1016/j.vaccine.2021.08.072",

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Yun, KW, Rhie, K, Kang, JH, Kim, KH, Ahn, JG, Kim, YJ, Eun, BW, Oh, SH, Cho, HK, Hong, YJ, Kim, NH, Kim, YK, Lee, H, Lee, T, Kim, HM, Cho, EY, Kim, CS, Park, SE, Oh, CE, Jo, DS, Song, ES, Lee, J, Choi, JH, Lee, JK, Lee, HJ & Choi, EH 2021, 'Emergence of serotype 10A-ST11189 among pediatric invasive pneumococcal diseases, South Korea, 2014–2019', Vaccine, vol. 39, no. 40, pp. 5787-5793. https://doi.org/10.1016/j.vaccine.2021.08.072

TY - JOUR

T1 - Emergence of serotype 10A-ST11189 among pediatric invasive pneumococcal diseases, South Korea, 2014–2019

AU - Yun, Ki Wook

AU - Rhie, Kyuyol

AU - Kang, Jin Han

AU - Kim, Kyung Hyo

AU - Ahn, Jong Gyun

AU - Kim, Yae Jean

AU - Eun, Byung Wook

AU - Oh, Sung Hee

AU - Cho, Hye Kyung

AU - Hong, Young Jin

AU - Kim, Nam Hee

AU - Kim, Yun Kyung

AU - Lee, Hyunju

AU - Lee, Taekjin

AU - Kim, Hwang Min

AU - Cho, Eun Young

AU - Kim, Chun Soo

AU - Park, Su Eun

AU - Oh, Chi Eun

AU - Jo, Dae Sun

AU - Song, Eun Song

AU - Lee, Jina

AU - Choi, Jae Hong

AU - Lee, Joon Kee

AU - Lee, Hoan Jong

AU - Choi, Eun Hwa

PY - 2021/9/24

Y1 - 2021/9/24

N2 - Replacement with nonvaccine serotypes (NVTs) among invasive pneumococcal diseases (IPDs) after the introduction of extended-valency pneumococcal conjugate vaccines varies in predominant serotypes across countries. This study analyzed changes in serotype distribution through serotyping, multilocus sequence typing, and antimicrobial susceptibility testing of 168 pediatric IPD isolates obtained from a multihospital-based surveillance system during 2014–2019 in South Korea. Vaccine serotypes (VTs) accounted for 16.1% (19A, 10.1%; 6A, 1.8%; and 19F 1.8%), 82.1% were NVTs (10A, 23.8%; 15A, 8.3%; 12F, 6.5%; 15C, 6.5%; and 15B, 6.0%), and three (1.8%) were nontypeable. Serotype 10A was the most common serotype, with a significant increase from 11.5% in 2014 to 33.3% in 2019 (p < 0.05 for the trend). Other NVTs decreased from 70.4% to 41.7% between 2015 and 2019, most notably in serotype 12F (from 14.8% to 0%). Almost all (95.0%) serotype 10A isolates were ST11189, which were multidrug resistant.

AB - Replacement with nonvaccine serotypes (NVTs) among invasive pneumococcal diseases (IPDs) after the introduction of extended-valency pneumococcal conjugate vaccines varies in predominant serotypes across countries. This study analyzed changes in serotype distribution through serotyping, multilocus sequence typing, and antimicrobial susceptibility testing of 168 pediatric IPD isolates obtained from a multihospital-based surveillance system during 2014–2019 in South Korea. Vaccine serotypes (VTs) accounted for 16.1% (19A, 10.1%; 6A, 1.8%; and 19F 1.8%), 82.1% were NVTs (10A, 23.8%; 15A, 8.3%; 12F, 6.5%; 15C, 6.5%; and 15B, 6.0%), and three (1.8%) were nontypeable. Serotype 10A was the most common serotype, with a significant increase from 11.5% in 2014 to 33.3% in 2019 (p < 0.05 for the trend). Other NVTs decreased from 70.4% to 41.7% between 2015 and 2019, most notably in serotype 12F (from 14.8% to 0%). Almost all (95.0%) serotype 10A isolates were ST11189, which were multidrug resistant.

KW - Children

KW - Genotype

KW - Serotype

KW - Streptococcus pneumoniae

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U2 - 10.1016/j.vaccine.2021.08.072

DO - 10.1016/j.vaccine.2021.08.072

M3 - Article

C2 - 34465475

AN - SCOPUS:85113854745

SN - 0264-410X

VL - 39

SP - 5787

EP - 5793

JO - Vaccine

JF - Vaccine

IS - 40

ER -

Emergence of serotype 10A-ST11189 among pediatric invasive pneumococcal diseases, South Korea, 2014–2019

Abstract

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Keywords

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