Emergence of serotype 10A-ST11189 among pediatric invasive pneumococcal diseases, South Korea, 2014–2019

Ki Wook Yun, Kyuyol Rhie, Jin Han Kang, Kyung Hyo Kim, Jong Gyun Ahn, Yae Jean Kim, Byung Wook Eun, Sung Hee Oh, Hye Kyung Cho, Young Jin Hong, Nam Hee Kim, Yun Kyung Kim, Hyunju Lee, Taekjin Lee, Hwang Min Kim, Eun Young Cho, Chun Soo Kim, Su Eun Park, Chi Eun Oh, Dae Sun JoEun Song Song, Jina Lee, Jae Hong Choi, Joon Kee Lee, Hoan Jong Lee, Eun Hwa Choi

Research output: Contribution to journalArticlepeer-review

1 Scopus citations

Abstract

Replacement with nonvaccine serotypes (NVTs) among invasive pneumococcal diseases (IPDs) after the introduction of extended-valency pneumococcal conjugate vaccines varies in predominant serotypes across countries. This study analyzed changes in serotype distribution through serotyping, multilocus sequence typing, and antimicrobial susceptibility testing of 168 pediatric IPD isolates obtained from a multihospital-based surveillance system during 2014–2019 in South Korea. Vaccine serotypes (VTs) accounted for 16.1% (19A, 10.1%; 6A, 1.8%; and 19F 1.8%), 82.1% were NVTs (10A, 23.8%; 15A, 8.3%; 12F, 6.5%; 15C, 6.5%; and 15B, 6.0%), and three (1.8%) were nontypeable. Serotype 10A was the most common serotype, with a significant increase from 11.5% in 2014 to 33.3% in 2019 (p < 0.05 for the trend). Other NVTs decreased from 70.4% to 41.7% between 2015 and 2019, most notably in serotype 12F (from 14.8% to 0%). Almost all (95.0%) serotype 10A isolates were ST11189, which were multidrug resistant.

Original languageEnglish
Pages (from-to)5787-5793
Number of pages7
JournalVaccine
Volume39
Issue number40
DOIs
StatePublished - 24 Sep 2021

Keywords

  • Children
  • Genotype
  • Serotype
  • Streptococcus pneumoniae

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