Embolization of Vascular Malformations via In Situ Photocrosslinking of Mechanically Reinforced Alginate Microfibers using an Optical-Fiber-Integrated Microfluidic Device

Jongkyeong Lim, Geunho Choi, Kye Il Joo, Hyung Joon Cha, Joonwon Kim

Research output: Contribution to journalArticlepeer-review

33 Scopus citations

Abstract

Embolization, which is a minimally invasive endovascular treatment, is a safe and effective procedure for treating vascular malformations (e.g., aneurysms). Hydrogel microfibers obtained via spatiotemporally controllable in situ photocrosslinking exhibit great potential for embolizing aneurysms. However, this process is challenging because of the absence of biocompatible and morphologically stable hydrogels and the difficulty in continuously spinning the microfibers via in situ photocrosslinking in extreme endovascular environments such as those involving a tortuous geometry and high absorbance. A double-crosslinked alginate-based hydrogel with tantalum nanopowder (DAT) that exploits the synergistic effect of covalent crosslinking by visible-light irradiation and ionic crosslinking using Ca2+, which is present in the blood, is developed in this study. Furthermore, an effective strategy to design and produce an optical-fiber-integrated microfluidic device (OFI-MD) that can continuously spin hydrogel microfibers via in situ photocrosslinking in extreme endovascular environments is proposed. As an embolic material, DAT exhibits promising characteristics such as radiopacity, nondissociation, nonswelling, and constant mechanical strength in blood, in addition to excellent cyto- and hemo-compatibilities. Using OFI-MD to spin DAT microfibers continuously can help fill aneurysms safely, uniformly, and completely within the endovascular simulator without generating microscopic fragments, which demonstrates its potential as an effective embolization strategy.

Original languageEnglish
Article number2006759
JournalAdvanced Materials
Volume33
Issue number14
DOIs
StatePublished - 8 Apr 2021

Bibliographical note

Funding Information:
J.L. and G.C. contributed equally to this work. This research was supported by the Korea Health Technology R&D Project (Grant number: HI15C0001) through the Korea Health Industry Development Institute funded by the Ministry of Health & Welfare, Korea (to J.K.) and the National Research Foundation (Grant numbers: NRF‐2020M3H4A1A03082879 and 2018R1A2B3003758) funded by the Ministry of Science and ICT, Korea (to H.J.C.). The animal study was performed in accordance with the guidelines approved by the Institutional Animal Care and Use Committee of POSTECH (POSTECH IACUC‐2020‐0089). Dog blood was acquired from Korea Animal Blood Bank. HUVECs were obtained from Lonza.

Funding Information:
J.L. and G.C. contributed equally to this work. This research was supported by the Korea Health Technology R&D Project (Grant number: HI15C0001) through the Korea Health Industry Development Institute funded by the Ministry of Health & Welfare, Korea (to J.K.) and the National Research Foundation (Grant numbers: NRF-2020M3H4A1A03082879 and 2018R1A2B3003758) funded by the Ministry of Science and ICT, Korea (to H.J.C.). The animal study was performed in accordance with the guidelines approved by the Institutional Animal Care and Use Committee of POSTECH (POSTECH IACUC-2020-0089). Dog blood was acquired from Korea Animal Blood Bank. HUVECs were obtained from Lonza.

Publisher Copyright:
© 2021 Wiley-VCH GmbH

Keywords

  • embolization
  • hydrogel microfibers
  • in situ photocrosslinking
  • microfluidic devices
  • nature-derived biomaterials

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