Elucidating molecular mechanisms of acquired resistance to BRAF inhibitors in melanoma using a microfluidic device and deep sequencing

Medicine & Life Sciences

• Lab-On-A-Chip Devices 100%
• High-Throughput Nucleotide Sequencing 69%
• Melanoma 60%
• Vemurafenib 53%
• Clone Cells 43%
• Mutation 40%
• Transcriptome 33%
• Microphthalmia-Associated Transcription Factor 27%
• Phenotype 21%
• Exome 21%
• Microfluidics 21%
• Melanocytes 20%
• Mitogen-Activated Protein Kinases 18%
• Disease Progression 14%
• Transcription Factors 13%
• Genome 12%
• Gene Expression 10%
• Cell Line 10%
• Therapeutics 8%

Agriculture & Biology

• microfluidic technology 90%
• high-throughput nucleotide sequencing 86%
• melanoma 84%
• mutation 49%
• clones 37%
• transcriptome 32%
• therapeutics 28%
• transcription factors 28%
• phenotype 24%
• disease progression 23%
• melanocytes 23%
• mitogen-activated protein kinase 19%
• cell lines 13%
• gene expression 11%
• genome 10%

Earth & Environmental Sciences

• mutation 72%
• inhibitor 67%
• clone 58%
• phenotype 39%
• therapy 38%
• gene expression 21%
• genome 17%
• protein 13%
• cell 11%