Electrospinning of polysaccharides for regenerative medicine

Kuen Yong Lee, Lim Jeong, Yun Ok Kang, Seung Jin Lee, Won Ho Park

Research output: Contribution to journalReview articlepeer-review

439 Scopus citations

Abstract

Electrospinning techniques enable the production of continuous fibers with dimensions on the scale of nanometers from a wide range of natural and synthetic polymers. The number of recent studies regarding electrospun polysaccharides and their derivatives, which are potentially useful for regenerative medicine, is increasing dramatically. However, difficulties regarding the processibility of the polysaccharides (e.g., poor solubility and high surface tension) have limited their application. In this review, we summarize the characteristics of various polysaccharides such as alginate, cellulose, chitin, chitosan, hyaluronic acid, starch, dextran, and heparin, which are either currently being used or have potential to be used for electrospinning. The recent progress of nanofiber matrices electrospun from polysaccharides and their biomedical applications in tissue engineering, wound dressings, drug delivery, and enzyme immobilization are discussed.

Original languageEnglish
Pages (from-to)1020-1032
Number of pages13
JournalAdvanced Drug Delivery Reviews
Volume61
Issue number12
DOIs
StatePublished - 5 Oct 2009

Keywords

  • Electrospinning
  • Nanofiber
  • Polysaccharide
  • Regenerative medicine

Fingerprint

Dive into the research topics of 'Electrospinning of polysaccharides for regenerative medicine'. Together they form a unique fingerprint.

Cite this