TY - JOUR
T1 - Electrospinning of polysaccharides for regenerative medicine
AU - Lee, Kuen Yong
AU - Jeong, Lim
AU - Kang, Yun Ok
AU - Lee, Seung Jin
AU - Park, Won Ho
N1 - Funding Information:
This work was financially supported by the Biotechnology Development Program (grant number 850-20080090) funded by the Ministry of Education, Science, and Technology (MEST) of Korea.
PY - 2009/10/5
Y1 - 2009/10/5
N2 - Electrospinning techniques enable the production of continuous fibers with dimensions on the scale of nanometers from a wide range of natural and synthetic polymers. The number of recent studies regarding electrospun polysaccharides and their derivatives, which are potentially useful for regenerative medicine, is increasing dramatically. However, difficulties regarding the processibility of the polysaccharides (e.g., poor solubility and high surface tension) have limited their application. In this review, we summarize the characteristics of various polysaccharides such as alginate, cellulose, chitin, chitosan, hyaluronic acid, starch, dextran, and heparin, which are either currently being used or have potential to be used for electrospinning. The recent progress of nanofiber matrices electrospun from polysaccharides and their biomedical applications in tissue engineering, wound dressings, drug delivery, and enzyme immobilization are discussed.
AB - Electrospinning techniques enable the production of continuous fibers with dimensions on the scale of nanometers from a wide range of natural and synthetic polymers. The number of recent studies regarding electrospun polysaccharides and their derivatives, which are potentially useful for regenerative medicine, is increasing dramatically. However, difficulties regarding the processibility of the polysaccharides (e.g., poor solubility and high surface tension) have limited their application. In this review, we summarize the characteristics of various polysaccharides such as alginate, cellulose, chitin, chitosan, hyaluronic acid, starch, dextran, and heparin, which are either currently being used or have potential to be used for electrospinning. The recent progress of nanofiber matrices electrospun from polysaccharides and their biomedical applications in tissue engineering, wound dressings, drug delivery, and enzyme immobilization are discussed.
KW - Electrospinning
KW - Nanofiber
KW - Polysaccharide
KW - Regenerative medicine
UR - http://www.scopus.com/inward/record.url?scp=70349814179&partnerID=8YFLogxK
U2 - 10.1016/j.addr.2009.07.006
DO - 10.1016/j.addr.2009.07.006
M3 - Review article
C2 - 19643155
AN - SCOPUS:70349814179
VL - 61
SP - 1020
EP - 1032
JO - Advanced Drug Delivery Reviews
JF - Advanced Drug Delivery Reviews
SN - 0169-409X
IS - 12
ER -