Electrospinning of polysaccharides for regenerative medicine

Kuen Yong Lee, Lim Jeong, Yun Ok Kang, Seung Jin Lee, Won Ho Park

Research output: Contribution to journalReview articlepeer-review

492 Scopus citations


Electrospinning techniques enable the production of continuous fibers with dimensions on the scale of nanometers from a wide range of natural and synthetic polymers. The number of recent studies regarding electrospun polysaccharides and their derivatives, which are potentially useful for regenerative medicine, is increasing dramatically. However, difficulties regarding the processibility of the polysaccharides (e.g., poor solubility and high surface tension) have limited their application. In this review, we summarize the characteristics of various polysaccharides such as alginate, cellulose, chitin, chitosan, hyaluronic acid, starch, dextran, and heparin, which are either currently being used or have potential to be used for electrospinning. The recent progress of nanofiber matrices electrospun from polysaccharides and their biomedical applications in tissue engineering, wound dressings, drug delivery, and enzyme immobilization are discussed.

Original languageEnglish
Pages (from-to)1020-1032
Number of pages13
JournalAdvanced Drug Delivery Reviews
Issue number12
StatePublished - 5 Oct 2009

Bibliographical note

Funding Information:
This work was financially supported by the Biotechnology Development Program (grant number 850-20080090) funded by the Ministry of Education, Science, and Technology (MEST) of Korea.


  • Electrospinning
  • Nanofiber
  • Polysaccharide
  • Regenerative medicine


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