Electrophysiological evidence for the role of substance P in retinohypothalamic transmission in the rat

Yang In Kim; Si Hyun Kim; Do Young Kim; Hyang Woon Lee; Hyung Chul Shin; Jun Mo Chung; Hee Chul Han; Heung Sik Na; Seung Kil Hong

doi:10.1016/S0304-3940(99)00681-3

Electrophysiological evidence for the role of substance P in retinohypothalamic transmission in the rat

Yang In Kim, Si Hyun Kim, Do Young Kim, Hyang Woon Lee, Hyung Chul Shin, Jun Mo Chung, Hee Chul Han, Heung Sik Na, Seung Kil Hong

Research output: Contribution to journal › Article › peer-review

15 Scopus citations

Abstract

The retinohypothalamic tract (RHT) is a neural pathway through which photic time cues are delivered directly to the mammalian circadian pacemaker in the suprachiasmatic nucleus (SCN). Although the excitatory amino acid glutamate is the primary neurotransmitter in the RHT, other substances such as substance P (SP) also have been suggested to play a role. The present study tested the hypothesis that SP participates in retinohypothalamic transmission and selectively modulates either N-methyl-D-aspartate (NMDA) or non-NMDA receptor-mediated neurotransmission. The SP antagonist L-703,606 depressed the excitatory postsynaptic current (EPSC) evoked by optic nerve stimulation in SCN neurons in rat hypothalamic slices. The SP antagonist also had a similar depressive effect on the NMDA and non-NMDA receptor-mediated components of the EPSC. These results suggest that SP is an excitatory neuromodulator contributing to the expression of both the NMDA and non-NMDA receptor-mediated components of retinohypothalamic transmission. Copyright (C) 1999 Elsevier Science Ireland Ltd.

Original language	English
Pages (from-to)	99-102
Number of pages	4
Journal	Neuroscience Letters
Volume	274
Issue number	2
DOIs	https://doi.org/10.1016/S0304-3940(99)00681-3
State	Published - 22 Oct 1999

Bibliographical note

Funding Information:
The authors are grateful to Dr. C. Allen for his constructive comments on the earlier drafts of this paper. This research was supported by The Hallym Academy of Sciences, KUMS Institute of Medical Sciences and Korea Research Foundation (1998–001-F00125).

Keywords

Circadian rhythm
Electrophysiology
Neuromodulator
Neurotransmitter
Retinohypothalamic transmission
Substance P
Suprachiasmatic nucleus

Access to Document

10.1016/S0304-3940(99)00681-3

Cite this

@article{858ace75dd0848db910cb261a0bca9e8,

title = "Electrophysiological evidence for the role of substance P in retinohypothalamic transmission in the rat",

abstract = "The retinohypothalamic tract (RHT) is a neural pathway through which photic time cues are delivered directly to the mammalian circadian pacemaker in the suprachiasmatic nucleus (SCN). Although the excitatory amino acid glutamate is the primary neurotransmitter in the RHT, other substances such as substance P (SP) also have been suggested to play a role. The present study tested the hypothesis that SP participates in retinohypothalamic transmission and selectively modulates either N-methyl-D-aspartate (NMDA) or non-NMDA receptor-mediated neurotransmission. The SP antagonist L-703,606 depressed the excitatory postsynaptic current (EPSC) evoked by optic nerve stimulation in SCN neurons in rat hypothalamic slices. The SP antagonist also had a similar depressive effect on the NMDA and non-NMDA receptor-mediated components of the EPSC. These results suggest that SP is an excitatory neuromodulator contributing to the expression of both the NMDA and non-NMDA receptor-mediated components of retinohypothalamic transmission. Copyright (C) 1999 Elsevier Science Ireland Ltd.",

keywords = "Circadian rhythm, Electrophysiology, Neuromodulator, Neurotransmitter, Retinohypothalamic transmission, Substance P, Suprachiasmatic nucleus",

author = "Kim, {Yang In} and Kim, {Si Hyun} and Kim, {Do Young} and Lee, {Hyang Woon} and Shin, {Hyung Chul} and Chung, {Jun Mo} and Han, {Hee Chul} and Na, {Heung Sik} and Hong, {Seung Kil}",

note = "Funding Information: The authors are grateful to Dr. C. Allen for his constructive comments on the earlier drafts of this paper. This research was supported by The Hallym Academy of Sciences, KUMS Institute of Medical Sciences and Korea Research Foundation (1998–001-F00125).",

year = "1999",

month = oct,

day = "22",

doi = "10.1016/S0304-3940(99)00681-3",

language = "English",

volume = "274",

pages = "99--102",

journal = "Neuroscience Letters",

issn = "0304-3940",

publisher = "Elsevier Ireland Ltd",

number = "2",

}

TY - JOUR

T1 - Electrophysiological evidence for the role of substance P in retinohypothalamic transmission in the rat

AU - Kim, Yang In

AU - Kim, Si Hyun

AU - Kim, Do Young

AU - Lee, Hyang Woon

AU - Shin, Hyung Chul

AU - Chung, Jun Mo

AU - Han, Hee Chul

AU - Na, Heung Sik

AU - Hong, Seung Kil

N1 - Funding Information: The authors are grateful to Dr. C. Allen for his constructive comments on the earlier drafts of this paper. This research was supported by The Hallym Academy of Sciences, KUMS Institute of Medical Sciences and Korea Research Foundation (1998–001-F00125).

PY - 1999/10/22

Y1 - 1999/10/22

N2 - The retinohypothalamic tract (RHT) is a neural pathway through which photic time cues are delivered directly to the mammalian circadian pacemaker in the suprachiasmatic nucleus (SCN). Although the excitatory amino acid glutamate is the primary neurotransmitter in the RHT, other substances such as substance P (SP) also have been suggested to play a role. The present study tested the hypothesis that SP participates in retinohypothalamic transmission and selectively modulates either N-methyl-D-aspartate (NMDA) or non-NMDA receptor-mediated neurotransmission. The SP antagonist L-703,606 depressed the excitatory postsynaptic current (EPSC) evoked by optic nerve stimulation in SCN neurons in rat hypothalamic slices. The SP antagonist also had a similar depressive effect on the NMDA and non-NMDA receptor-mediated components of the EPSC. These results suggest that SP is an excitatory neuromodulator contributing to the expression of both the NMDA and non-NMDA receptor-mediated components of retinohypothalamic transmission. Copyright (C) 1999 Elsevier Science Ireland Ltd.

AB - The retinohypothalamic tract (RHT) is a neural pathway through which photic time cues are delivered directly to the mammalian circadian pacemaker in the suprachiasmatic nucleus (SCN). Although the excitatory amino acid glutamate is the primary neurotransmitter in the RHT, other substances such as substance P (SP) also have been suggested to play a role. The present study tested the hypothesis that SP participates in retinohypothalamic transmission and selectively modulates either N-methyl-D-aspartate (NMDA) or non-NMDA receptor-mediated neurotransmission. The SP antagonist L-703,606 depressed the excitatory postsynaptic current (EPSC) evoked by optic nerve stimulation in SCN neurons in rat hypothalamic slices. The SP antagonist also had a similar depressive effect on the NMDA and non-NMDA receptor-mediated components of the EPSC. These results suggest that SP is an excitatory neuromodulator contributing to the expression of both the NMDA and non-NMDA receptor-mediated components of retinohypothalamic transmission. Copyright (C) 1999 Elsevier Science Ireland Ltd.

KW - Circadian rhythm

KW - Electrophysiology

KW - Neuromodulator

KW - Neurotransmitter

KW - Retinohypothalamic transmission

KW - Substance P

KW - Suprachiasmatic nucleus

UR - http://www.scopus.com/inward/record.url?scp=0032881393&partnerID=8YFLogxK

U2 - 10.1016/S0304-3940(99)00681-3

DO - 10.1016/S0304-3940(99)00681-3

M3 - Article

C2 - 10553947

AN - SCOPUS:0032881393

SN - 0304-3940

VL - 274

SP - 99

EP - 102

JO - Neuroscience Letters

JF - Neuroscience Letters

IS - 2

ER -

Electrophysiological evidence for the role of substance P in retinohypothalamic transmission in the rat

Abstract

Bibliographical note

Keywords

Access to Document

Fingerprint

Cite this