Abstract
We have accomplished the effective signal amplification of surface enhanced Raman scattering (SERS) by electrokinetics-based sample enrichments. This signal amplification provides a rapid and simple solution for label-free and sensitive biomolecular detection with limited amount of samples. Biomolecules can be concentrated onto SERS-active surface by applying an electric field. The SERS detection limits of adenine reduced 8 orders of magnitude (from 1 PM to 10 fM) within 5 minutes using an electrical field of 0.6 V/cm. The integrated microfluidic SERS with electrokinetics-based sample preconcentration method can be further utilized for label-free genomic, proteomic, forensic, diagnostic, water, and environmental monitoring applications.
| Original language | English |
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| Title of host publication | Proceedings of the 11th International Conference on Miniaturized Systems for Chemistry and Life Sciences, uTAS 2007 |
| Editors | Jean-Louis Viovy, Patrick Tabeling, Stephanie Descroix, Laurent Malaquin |
| Publisher | Chemical and Biological Microsystems Society |
| Pages | 1182-1184 |
| Number of pages | 3 |
| ISBN (Electronic) | 9780979806407 |
| State | Published - 2007 |
| Event | 11th International Conference on Miniaturized Systems for Chemistry and Life Sciences, uTAS 2007 - Paris, France Duration: 7 Oct 2007 → 11 Oct 2007 |
Publication series
| Name | Proceedings of the 11th International Conference on Miniaturized Systems for Chemistry and Life Sciences, uTAS 2007 |
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Conference
| Conference | 11th International Conference on Miniaturized Systems for Chemistry and Life Sciences, uTAS 2007 |
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| Country/Territory | France |
| City | Paris |
| Period | 7/10/07 → 11/10/07 |
Bibliographical note
Publisher Copyright:© 2007 CBMS.
Keywords
- Electrokinetics
- Keyword: Preconcentration
- Label-Free
- Surface Enhanced Raman Scattering