Electroconvulsive shock reduces inositol 1,4,5-trisphosphate 3-kinase mRNA expression in rat dentate gyrus

Hyun Kim; Jae Pil Ko; Ung Gu Kang; Joo Bae Park; Hyung Lae Kim; Young Han Lee; Yong Sik Kim

Electroconvulsive shock reduces inositol 1,4,5-trisphosphate 3-kinase mRNA expression in rat dentate gyrus

Hyun Kim, Jae Pil Ko, Ung Gu Kang, Joo Bae Park, Hyung Lae Kim, Young Han Lee, Yong Sik Kim

Department of Biochemistry

Research output: Contribution to journal › Article › peer-review

28 Scopus citations

Abstract

We investigated the expression of inositol 1,4,5-trisphosphate (InsP₃) 3- kinase mRNA after a single electroconvulsive shock (ECS) with in situ hybridization histochemistry in rat brain. At 6 h after ECS, the expression was markedly decreased in the dentate gyrus, and the decrease was maintained until 9 h with a slight recovery. The InsP₃ 3-kinase mRNA content returned to basal levels after 12 h. We could not detect any apparent changes in the expression of InsP₃ 3-kinase mRNA in the CA1-CA3 areas of hippocampus, the striatum, and the cerebral cortex at any time point examined. In the temporal pattern, the reduction of the expression in the dentate gyrus was preceded by the induction of c-fos after ECS. These observations suggest that the InsP₃ 3-kinase might be one of the genes whose expression can be altered by ECS.

Original language	English
Pages (from-to)	1991-1994
Number of pages	4
Journal	Journal of Neurochemistry
Volume	63
Issue number	5
State	Published - Nov 1994

Keywords

Dentate gyrus
Electroconvulsive shock
In situ hybridization histochemistry
Inositol 1,4,5- trisphosphate 3-kinase
c-fos

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@article{296b5192e25048d4ae3f353ac96e7cdc,

title = "Electroconvulsive shock reduces inositol 1,4,5-trisphosphate 3-kinase mRNA expression in rat dentate gyrus",

abstract = "We investigated the expression of inositol 1,4,5-trisphosphate (InsP3) 3- kinase mRNA after a single electroconvulsive shock (ECS) with in situ hybridization histochemistry in rat brain. At 6 h after ECS, the expression was markedly decreased in the dentate gyrus, and the decrease was maintained until 9 h with a slight recovery. The InsP3 3-kinase mRNA content returned to basal levels after 12 h. We could not detect any apparent changes in the expression of InsP3 3-kinase mRNA in the CA1-CA3 areas of hippocampus, the striatum, and the cerebral cortex at any time point examined. In the temporal pattern, the reduction of the expression in the dentate gyrus was preceded by the induction of c-fos after ECS. These observations suggest that the InsP3 3-kinase might be one of the genes whose expression can be altered by ECS.",

keywords = "Dentate gyrus, Electroconvulsive shock, In situ hybridization histochemistry, Inositol 1,4,5- trisphosphate 3-kinase, c-fos",

author = "Hyun Kim and Ko, {Jae Pil} and Kang, {Ung Gu} and Park, {Joo Bae} and Kim, {Hyung Lae} and Lee, {Young Han} and Kim, {Yong Sik}",

year = "1994",

month = nov,

language = "English",

volume = "63",

pages = "1991--1994",

journal = "Journal of Neurochemistry",

issn = "0022-3042",

publisher = "Wiley-Blackwell Publishing Ltd",

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TY - JOUR

T1 - Electroconvulsive shock reduces inositol 1,4,5-trisphosphate 3-kinase mRNA expression in rat dentate gyrus

AU - Kim, Hyun

AU - Ko, Jae Pil

AU - Kang, Ung Gu

AU - Park, Joo Bae

AU - Kim, Hyung Lae

AU - Lee, Young Han

AU - Kim, Yong Sik

PY - 1994/11

Y1 - 1994/11

N2 - We investigated the expression of inositol 1,4,5-trisphosphate (InsP3) 3- kinase mRNA after a single electroconvulsive shock (ECS) with in situ hybridization histochemistry in rat brain. At 6 h after ECS, the expression was markedly decreased in the dentate gyrus, and the decrease was maintained until 9 h with a slight recovery. The InsP3 3-kinase mRNA content returned to basal levels after 12 h. We could not detect any apparent changes in the expression of InsP3 3-kinase mRNA in the CA1-CA3 areas of hippocampus, the striatum, and the cerebral cortex at any time point examined. In the temporal pattern, the reduction of the expression in the dentate gyrus was preceded by the induction of c-fos after ECS. These observations suggest that the InsP3 3-kinase might be one of the genes whose expression can be altered by ECS.

AB - We investigated the expression of inositol 1,4,5-trisphosphate (InsP3) 3- kinase mRNA after a single electroconvulsive shock (ECS) with in situ hybridization histochemistry in rat brain. At 6 h after ECS, the expression was markedly decreased in the dentate gyrus, and the decrease was maintained until 9 h with a slight recovery. The InsP3 3-kinase mRNA content returned to basal levels after 12 h. We could not detect any apparent changes in the expression of InsP3 3-kinase mRNA in the CA1-CA3 areas of hippocampus, the striatum, and the cerebral cortex at any time point examined. In the temporal pattern, the reduction of the expression in the dentate gyrus was preceded by the induction of c-fos after ECS. These observations suggest that the InsP3 3-kinase might be one of the genes whose expression can be altered by ECS.

KW - Dentate gyrus

KW - Electroconvulsive shock

KW - In situ hybridization histochemistry

KW - Inositol 1,4,5- trisphosphate 3-kinase

KW - c-fos

UR - http://www.scopus.com/inward/record.url?scp=0028028487&partnerID=8YFLogxK

M3 - Article

C2 - 7931359

AN - SCOPUS:0028028487

SN - 0022-3042

VL - 63

SP - 1991

EP - 1994

JO - Journal of Neurochemistry

JF - Journal of Neurochemistry

IS - 5

ER -

Electroconvulsive shock reduces inositol 1,4,5-trisphosphate 3-kinase mRNA expression in rat dentate gyrus

Abstract

Keywords

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