Electrochemical detection of dopamine using a bare indium-tin oxide electrode and scan rate control

Byung Kwon Kim, Ji Young Lee, Jun Hui Park, Juhyoun Kwak

Research output: Contribution to journalArticlepeer-review

13 Scopus citations

Abstract

We report sensitive and selective electrochemical detection of dopamine (DA), a neurotransmitter that plays an important role in organisms. The detection of DA is often prevented by the presence of interfering molecules. Therefore, developing a selective and sensitive technology for detection of DA is necessary. The proposed method simply achieves selective and sensitive detection of DA by scan rate control on bare indium-tin oxide (ITO) electrodes. In the case of a low scan rate (50 mV s-1), the anodic peaks of DA and ascorbic acid (AA) appeared at similar potentials (ca. 0.1 V) and both of them showed high anodic peaks. On the other hand, with a high scan rate (5 V s-1), the anodic peak of AA almost disappeared, but the DA peak was still high because of the adsorption of DA to the electrode. The detection limit of this method is 1 nM of DA in the presence of 0.1 mM of AA and 100 nM of DA in human blood serum.

Original languageEnglish
Pages (from-to)7-12
Number of pages6
JournalJournal of Electroanalytical Chemistry
Volume708
DOIs
StatePublished - 2013

Keywords

  • Ascorbic acid
  • Dopamine
  • ITO
  • Peak deconvolution
  • Scan rate

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