Efficient synthesis of 2-substituted 2,3-dihydro-4-quinolones as potential intermediates for 2-substituted 1,2,3,4-tetrahydro-4-quinolone antitumor agents

Sun Choi; Keumnyeo Jung; Jaesang Ryu

doi:10.1007/BF02968586

Efficient synthesis of 2-substituted 2,3-dihydro-4-quinolones as potential intermediates for 2-substituted 1,2,3,4-tetrahydro-4-quinolone antitumor agents

Sun Choi, Keumnyeo Jung, Jaesang Ryu

Pharmaceutical Sciences

Research output: Contribution to journal › Article › peer-review

12 Scopus citations

Abstract

An efficient method for the synthesis of optically active 2-substituted 2,3-dihydro-4-quinolones has been developed. The key features include the introduction of a chiral side chain and the construction of quinolone skeleton by Mitsunobu alkylation and hydroarylation, respectively.

Original language	English
Pages (from-to)	369-374
Number of pages	6
Journal	Archives of Pharmacal Research
Volume	29
Issue number	5
DOIs	https://doi.org/10.1007/BF02968586
State	Published - 31 May 2006

Bibliographical note

Funding Information:
This work was supported by the Ewha Womans University Research Grant of 2005.

Keywords

1,2,3,4-Tetrahydro-4-quinolone
2,3-Dihydro-4-quinolone
Antitumor agent
Hydroarylation
Mitsunobu
PtCl

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title = "Efficient synthesis of 2-substituted 2,3-dihydro-4-quinolones as potential intermediates for 2-substituted 1,2,3,4-tetrahydro-4-quinolone antitumor agents",

abstract = "An efficient method for the synthesis of optically active 2-substituted 2,3-dihydro-4-quinolones has been developed. The key features include the introduction of a chiral side chain and the construction of quinolone skeleton by Mitsunobu alkylation and hydroarylation, respectively.",

keywords = "1,2,3,4-Tetrahydro-4-quinolone, 2,3-Dihydro-4-quinolone, Antitumor agent, Hydroarylation, Mitsunobu, PtCl",

author = "Sun Choi and Keumnyeo Jung and Jaesang Ryu",

note = "Funding Information: This work was supported by the Ewha Womans University Research Grant of 2005.",

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AU - Choi, Sun

AU - Jung, Keumnyeo

AU - Ryu, Jaesang

N1 - Funding Information: This work was supported by the Ewha Womans University Research Grant of 2005.

PY - 2006/5/31

Y1 - 2006/5/31

N2 - An efficient method for the synthesis of optically active 2-substituted 2,3-dihydro-4-quinolones has been developed. The key features include the introduction of a chiral side chain and the construction of quinolone skeleton by Mitsunobu alkylation and hydroarylation, respectively.

AB - An efficient method for the synthesis of optically active 2-substituted 2,3-dihydro-4-quinolones has been developed. The key features include the introduction of a chiral side chain and the construction of quinolone skeleton by Mitsunobu alkylation and hydroarylation, respectively.

KW - 1,2,3,4-Tetrahydro-4-quinolone

KW - 2,3-Dihydro-4-quinolone

KW - Antitumor agent

KW - Hydroarylation

KW - Mitsunobu

KW - PtCl

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U2 - 10.1007/BF02968586

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ER -

Efficient synthesis of 2-substituted 2,3-dihydro-4-quinolones as potential intermediates for 2-substituted 1,2,3,4-tetrahydro-4-quinolone antitumor agents

Abstract

Bibliographical note

Keywords

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