Efficient synthesis of 2-substituted 2,3-dihydro-4-quinolones as potential intermediates for 2-substituted 1,2,3,4-tetrahydro-4-quinolone antitumor agents

Sun Choi, Keumnyeo Jung, Jaesang Ryu

Research output: Contribution to journalArticlepeer-review

14 Scopus citations

Abstract

An efficient method for the synthesis of optically active 2-substituted 2,3-dihydro-4-quinolones has been developed. The key features include the introduction of a chiral side chain and the construction of quinolone skeleton by Mitsunobu alkylation and hydroarylation, respectively.

Original languageEnglish
Pages (from-to)369-374
Number of pages6
JournalArchives of Pharmacal Research
Volume29
Issue number5
DOIs
StatePublished - 31 May 2006

Bibliographical note

Funding Information:
This work was supported by the Ewha Womans University Research Grant of 2005.

Keywords

  • 1,2,3,4-Tetrahydro-4-quinolone
  • 2,3-Dihydro-4-quinolone
  • Antitumor agent
  • Hydroarylation
  • Mitsunobu
  • PtCl

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