Abstract
An efficient method for the synthesis of optically active 2-substituted 2,3-dihydro-4-quinolones has been developed. The key features include the introduction of a chiral side chain and the construction of quinolone skeleton by Mitsunobu alkylation and hydroarylation, respectively.
Original language | English |
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Pages (from-to) | 369-374 |
Number of pages | 6 |
Journal | Archives of Pharmacal Research |
Volume | 29 |
Issue number | 5 |
DOIs | |
State | Published - 31 May 2006 |
Bibliographical note
Funding Information:This work was supported by the Ewha Womans University Research Grant of 2005.
Keywords
- 1,2,3,4-Tetrahydro-4-quinolone
- 2,3-Dihydro-4-quinolone
- Antitumor agent
- Hydroarylation
- Mitsunobu
- PtCl