Efficient synthesis and neuroprotective effect of substituted 1,3-diphenyl-2-propen-1-ones

Jae Chul Jung; Soyong Jang; Yongnam Lee; Dongguk Min; Eunyoung Lim; Heyin Jung; Miyeon Oh; Seikwan Oh; Mankil Jung

doi:10.1021/jm800221g

Efficient synthesis and neuroprotective effect of substituted 1,3-diphenyl-2-propen-1-ones

Jae Chul Jung, Soyong Jang, Yongnam Lee, Dongguk Min, Eunyoung Lim, Heyin Jung, Miyeon Oh, Seikwan Oh, Mankil Jung

Department of Molecular Medicine

Research output: Contribution to journal › Article › peer-review

30 Scopus citations

Abstract

An efficient synthesis involving a key aldol reaction and biological properties of 1,3-diphenyl-2-propen-1-ones 8-20 is described. The in vitro activity for 2,2-diphenyl-1-picrylhydrazyl (DPPH) radical scavenging of 10 and 11 was 2 times higher than that for resveratrol. Compounds 9 and 11 were the strongest in suppression of in vitro nitric oxide (NO) generation and antiexcitotoxicity. Molecular modeling proposes an electron-donating group at the para position of acetophenones that leads to a dramatic increase in the suppression of NO production.

Original language	English
Pages (from-to)	4054-4058
Number of pages	5
Journal	Journal of Medicinal Chemistry
Volume	51
Issue number	13
DOIs	https://doi.org/10.1021/jm800221g
State	Published - 10 Jul 2008

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abstract = "An efficient synthesis involving a key aldol reaction and biological properties of 1,3-diphenyl-2-propen-1-ones 8-20 is described. The in vitro activity for 2,2-diphenyl-1-picrylhydrazyl (DPPH) radical scavenging of 10 and 11 was 2 times higher than that for resveratrol. Compounds 9 and 11 were the strongest in suppression of in vitro nitric oxide (NO) generation and antiexcitotoxicity. Molecular modeling proposes an electron-donating group at the para position of acetophenones that leads to a dramatic increase in the suppression of NO production.",

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T1 - Efficient synthesis and neuroprotective effect of substituted 1,3-diphenyl-2-propen-1-ones

AU - Jung, Jae Chul

AU - Jang, Soyong

AU - Lee, Yongnam

AU - Min, Dongguk

AU - Lim, Eunyoung

AU - Jung, Heyin

AU - Oh, Miyeon

AU - Oh, Seikwan

AU - Jung, Mankil

PY - 2008/7/10

Y1 - 2008/7/10

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AB - An efficient synthesis involving a key aldol reaction and biological properties of 1,3-diphenyl-2-propen-1-ones 8-20 is described. The in vitro activity for 2,2-diphenyl-1-picrylhydrazyl (DPPH) radical scavenging of 10 and 11 was 2 times higher than that for resveratrol. Compounds 9 and 11 were the strongest in suppression of in vitro nitric oxide (NO) generation and antiexcitotoxicity. Molecular modeling proposes an electron-donating group at the para position of acetophenones that leads to a dramatic increase in the suppression of NO production.

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Efficient synthesis and neuroprotective effect of substituted 1,3-diphenyl-2-propen-1-ones

Abstract

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