Efficient singlet oxygen generation from sugar pendant C60 derivatives for photodynamic therapy

Shigenobu Yano; Masami Naemura; Akio Toshimitsu; Motofusa Akiyama; Atsushi Ikeda; Jun Ichi Kikuchi; Xiande Shen; Qian Duan; Atsushi Narumi; Masahiro Inoue; Kei Ohkubo; Shunichi Fukuzumi

doi:10.1039/c5cc07353g

Efficient singlet oxygen generation from sugar pendant C₆₀ derivatives for photodynamic therapy

Shigenobu Yano, Masami Naemura, Akio Toshimitsu, Motofusa Akiyama, Atsushi Ikeda, Jun Ichi Kikuchi, Xiande Shen, Qian Duan, Atsushi Narumi, Masahiro Inoue, Kei Ohkubo, Shunichi Fukuzumi

Department of Chemistry & Nanoscience

Research output: Contribution to journal › Article › peer-review

16 Scopus citations

Abstract

The amidation reaction between C₆₀ with an activated ester group (1) and acetylated Glc (AcGlc) with an amino group (2) was performed to yield the target AcGlc-pendant C₆₀ compound (3). The water soluble deacetylated compound, Glc-pendant C₆₀ compound (4), exhibited high photocytotoxicity against HeLa cells due to the more efficient singlet oxygen generation as compared with that of Glc-pendant azafulleroids.

Original language	English
Pages (from-to)	16605-16608
Number of pages	4
Journal	Chemical Communications
Volume	51
Issue number	93
DOIs	https://doi.org/10.1039/c5cc07353g
State	Published - 2015

Bibliographical note

Publisher Copyright:
© The Royal Society of Chemistry 2015.

Access to Document

10.1039/c5cc07353g

Cite this

@article{b0738faaffd2474db08b1131324fa84d,

title = "Efficient singlet oxygen generation from sugar pendant C60 derivatives for photodynamic therapy",

abstract = "The amidation reaction between C60 with an activated ester group (1) and acetylated Glc (AcGlc) with an amino group (2) was performed to yield the target AcGlc-pendant C60 compound (3). The water soluble deacetylated compound, Glc-pendant C60 compound (4), exhibited high photocytotoxicity against HeLa cells due to the more efficient singlet oxygen generation as compared with that of Glc-pendant azafulleroids.",

author = "Shigenobu Yano and Masami Naemura and Akio Toshimitsu and Motofusa Akiyama and Atsushi Ikeda and Kikuchi, {Jun Ichi} and Xiande Shen and Qian Duan and Atsushi Narumi and Masahiro Inoue and Kei Ohkubo and Shunichi Fukuzumi",

note = "Publisher Copyright: {\textcopyright} The Royal Society of Chemistry 2015.",

year = "2015",

doi = "10.1039/c5cc07353g",

language = "English",

volume = "51",

pages = "16605--16608",

journal = "Chemical Communications",

issn = "1359-7345",

publisher = "Royal Society of Chemistry",

number = "93",

}

TY - JOUR

T1 - Efficient singlet oxygen generation from sugar pendant C60 derivatives for photodynamic therapy

AU - Yano, Shigenobu

AU - Naemura, Masami

AU - Toshimitsu, Akio

AU - Akiyama, Motofusa

AU - Ikeda, Atsushi

AU - Kikuchi, Jun Ichi

AU - Shen, Xiande

AU - Duan, Qian

AU - Narumi, Atsushi

AU - Inoue, Masahiro

AU - Ohkubo, Kei

AU - Fukuzumi, Shunichi

PY - 2015

Y1 - 2015

N2 - The amidation reaction between C60 with an activated ester group (1) and acetylated Glc (AcGlc) with an amino group (2) was performed to yield the target AcGlc-pendant C60 compound (3). The water soluble deacetylated compound, Glc-pendant C60 compound (4), exhibited high photocytotoxicity against HeLa cells due to the more efficient singlet oxygen generation as compared with that of Glc-pendant azafulleroids.

AB - The amidation reaction between C60 with an activated ester group (1) and acetylated Glc (AcGlc) with an amino group (2) was performed to yield the target AcGlc-pendant C60 compound (3). The water soluble deacetylated compound, Glc-pendant C60 compound (4), exhibited high photocytotoxicity against HeLa cells due to the more efficient singlet oxygen generation as compared with that of Glc-pendant azafulleroids.

UR - http://www.scopus.com/inward/record.url?scp=84947475103&partnerID=8YFLogxK

U2 - 10.1039/c5cc07353g

DO - 10.1039/c5cc07353g

M3 - Article

C2 - 26420023

AN - SCOPUS:84947475103

SN - 1359-7345

VL - 51

SP - 16605

EP - 16608

JO - Chemical Communications

JF - Chemical Communications

IS - 93

ER -