Efficient radical scavenging ability of artepillin C, a major component of Brazilian propolis, and the mechanism

Ikuo Nakanishi; Yoshihiro Uto; Kei Ohkubo; Kentaro Miyazaki; Haruko Yakumaru; Shiro Urano; Haruhiro Okuda; Jun Ichi Ueda; Toshihiko Ozawa; Kiyoshi Fukuhara; Shunichi Fukuzumi; Hideko Nagasawa; Hitoshi Hori; Nobuo Ikota

doi:10.1039/b302098c

Efficient radical scavenging ability of artepillin C, a major component of Brazilian propolis, and the mechanism

Ikuo Nakanishi
, Yoshihiro Uto
, Kei Ohkubo
, Kentaro Miyazaki
, Haruko Yakumaru
, Shiro Urano
, Haruhiro Okuda
, Jun Ichi Ueda
, Toshihiko Ozawa
, Kiyoshi Fukuhara
, Shunichi Fukuzumi
, Hideko Nagasawa
, Hitoshi Hori
, Nobuo Ikota

Department of Chemistry & Nanoscience

Research output: Contribution to journal › Article › peer-review

53 Scopus citations

Abstract

Hydrogen transfer from artepillin C to cumylperoxyl radical was followed. It was found that artepillin C exhibits an efficient radical-scavenging activity against cumylperoxyl radical in an aprotic medium. The absence of an effect of Sc³⁺ on the k_HT values demonstrated that the hydrogen transfer from artepillin C to cumylperoxyl radical proceeds via one-step hydrogen atom transfer.

Original language	English
Pages (from-to)	1452-1454
Number of pages	3
Journal	Organic and Biomolecular Chemistry
Volume	1
Issue number	9
DOIs	https://doi.org/10.1039/b302098c
State	Published - 7 May 2003

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Nakanishi, I., Uto, Y., Ohkubo, K., Miyazaki, K., Yakumaru, H., Urano, S., Okuda, H., Ueda, J. I., Ozawa, T., Fukuhara, K., Fukuzumi, S., Nagasawa, H., Hori, H., & Ikota, N. (2003). Efficient radical scavenging ability of artepillin C, a major component of Brazilian propolis, and the mechanism. Organic and Biomolecular Chemistry, 1(9), 1452-1454. https://doi.org/10.1039/b302098c

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abstract = "Hydrogen transfer from artepillin C to cumylperoxyl radical was followed. It was found that artepillin C exhibits an efficient radical-scavenging activity against cumylperoxyl radical in an aprotic medium. The absence of an effect of Sc3+ on the kHT values demonstrated that the hydrogen transfer from artepillin C to cumylperoxyl radical proceeds via one-step hydrogen atom transfer.",

author = "Ikuo Nakanishi and Yoshihiro Uto and Kei Ohkubo and Kentaro Miyazaki and Haruko Yakumaru and Shiro Urano and Haruhiro Okuda and Ueda, \{Jun Ichi\} and Toshihiko Ozawa and Kiyoshi Fukuhara and Shunichi Fukuzumi and Hideko Nagasawa and Hitoshi Hori and Nobuo Ikota",

year = "2003",

month = may,

day = "7",

doi = "10.1039/b302098c",

language = "English",

volume = "1",

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Nakanishi, I, Uto, Y, Ohkubo, K, Miyazaki, K, Yakumaru, H, Urano, S, Okuda, H, Ueda, JI, Ozawa, T, Fukuhara, K, Fukuzumi, S, Nagasawa, H, Hori, H & Ikota, N 2003, 'Efficient radical scavenging ability of artepillin C, a major component of Brazilian propolis, and the mechanism', Organic and Biomolecular Chemistry, vol. 1, no. 9, pp. 1452-1454. https://doi.org/10.1039/b302098c

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T1 - Efficient radical scavenging ability of artepillin C, a major component of Brazilian propolis, and the mechanism

AU - Nakanishi, Ikuo

AU - Uto, Yoshihiro

AU - Ohkubo, Kei

AU - Miyazaki, Kentaro

AU - Yakumaru, Haruko

AU - Urano, Shiro

AU - Okuda, Haruhiro

AU - Ueda, Jun Ichi

AU - Ozawa, Toshihiko

AU - Fukuhara, Kiyoshi

AU - Fukuzumi, Shunichi

AU - Nagasawa, Hideko

AU - Hori, Hitoshi

AU - Ikota, Nobuo

PY - 2003/5/7

Y1 - 2003/5/7

N2 - Hydrogen transfer from artepillin C to cumylperoxyl radical was followed. It was found that artepillin C exhibits an efficient radical-scavenging activity against cumylperoxyl radical in an aprotic medium. The absence of an effect of Sc3+ on the kHT values demonstrated that the hydrogen transfer from artepillin C to cumylperoxyl radical proceeds via one-step hydrogen atom transfer.

AB - Hydrogen transfer from artepillin C to cumylperoxyl radical was followed. It was found that artepillin C exhibits an efficient radical-scavenging activity against cumylperoxyl radical in an aprotic medium. The absence of an effect of Sc3+ on the kHT values demonstrated that the hydrogen transfer from artepillin C to cumylperoxyl radical proceeds via one-step hydrogen atom transfer.

UR - https://www.scopus.com/pages/publications/0141905846

U2 - 10.1039/b302098c

DO - 10.1039/b302098c

M3 - Article

AN - SCOPUS:0141905846

SN - 1477-0520

VL - 1

SP - 1452

EP - 1454

JO - Organic and Biomolecular Chemistry

JF - Organic and Biomolecular Chemistry

IS - 9

ER -

Efficient radical scavenging ability of artepillin C, a major component of Brazilian propolis, and the mechanism

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