Efficient radical scavenging ability of artepillin C, a major component of Brazilian propolis, and the mechanism

Ikuo Nakanishi; Yoshihiro Uto; Kei Ohkubo; Kentaro Miyazaki; Haruko Yakumaru; Shiro Urano; Haruhiro Okuda; Jun Ichi Ueda; Toshihiko Ozawa; Kiyoshi Fukuhara; Shunichi Fukuzumi; Hideko Nagasawa; Hitoshi Hori; Nobuo Ikota

doi:10.1039/b302098c

Efficient radical scavenging ability of artepillin C, a major component of Brazilian propolis, and the mechanism

Ikuo Nakanishi, Yoshihiro Uto, Kei Ohkubo, Kentaro Miyazaki, Haruko Yakumaru, Shiro Urano, Haruhiro Okuda, Jun Ichi Ueda, Toshihiko Ozawa, Kiyoshi Fukuhara, Shunichi Fukuzumi, Hideko Nagasawa, Hitoshi Hori, Nobuo Ikota

Department of Chemistry & Nanoscience

Research output: Contribution to journal › Article › peer-review

52 Scopus citations

Abstract

Hydrogen transfer from artepillin C to cumylperoxyl radical was followed. It was found that artepillin C exhibits an efficient radical-scavenging activity against cumylperoxyl radical in an aprotic medium. The absence of an effect of Sc³⁺ on the k_HT values demonstrated that the hydrogen transfer from artepillin C to cumylperoxyl radical proceeds via one-step hydrogen atom transfer.

Original language	English
Pages (from-to)	1452-1454
Number of pages	3
Journal	Organic and Biomolecular Chemistry
Volume	1
Issue number	9
DOIs	https://doi.org/10.1039/b302098c
State	Published - 7 May 2003

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Nakanishi, I., Uto, Y., Ohkubo, K., Miyazaki, K., Yakumaru, H., Urano, S., Okuda, H., Ueda, J. I., Ozawa, T., Fukuhara, K., Fukuzumi, S., Nagasawa, H., Hori, H., & Ikota, N. (2003). Efficient radical scavenging ability of artepillin C, a major component of Brazilian propolis, and the mechanism. Organic and Biomolecular Chemistry, 1(9), 1452-1454. https://doi.org/10.1039/b302098c

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abstract = "Hydrogen transfer from artepillin C to cumylperoxyl radical was followed. It was found that artepillin C exhibits an efficient radical-scavenging activity against cumylperoxyl radical in an aprotic medium. The absence of an effect of Sc3+ on the kHT values demonstrated that the hydrogen transfer from artepillin C to cumylperoxyl radical proceeds via one-step hydrogen atom transfer.",

author = "Ikuo Nakanishi and Yoshihiro Uto and Kei Ohkubo and Kentaro Miyazaki and Haruko Yakumaru and Shiro Urano and Haruhiro Okuda and Ueda, \{Jun Ichi\} and Toshihiko Ozawa and Kiyoshi Fukuhara and Shunichi Fukuzumi and Hideko Nagasawa and Hitoshi Hori and Nobuo Ikota",

year = "2003",

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doi = "10.1039/b302098c",

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Nakanishi, I, Uto, Y, Ohkubo, K, Miyazaki, K, Yakumaru, H, Urano, S, Okuda, H, Ueda, JI, Ozawa, T, Fukuhara, K, Fukuzumi, S, Nagasawa, H, Hori, H & Ikota, N 2003, 'Efficient radical scavenging ability of artepillin C, a major component of Brazilian propolis, and the mechanism', Organic and Biomolecular Chemistry, vol. 1, no. 9, pp. 1452-1454. https://doi.org/10.1039/b302098c

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T1 - Efficient radical scavenging ability of artepillin C, a major component of Brazilian propolis, and the mechanism

AU - Nakanishi, Ikuo

AU - Uto, Yoshihiro

AU - Ohkubo, Kei

AU - Miyazaki, Kentaro

AU - Yakumaru, Haruko

AU - Urano, Shiro

AU - Okuda, Haruhiro

AU - Ueda, Jun Ichi

AU - Ozawa, Toshihiko

AU - Fukuhara, Kiyoshi

AU - Fukuzumi, Shunichi

AU - Nagasawa, Hideko

AU - Hori, Hitoshi

AU - Ikota, Nobuo

PY - 2003/5/7

Y1 - 2003/5/7

N2 - Hydrogen transfer from artepillin C to cumylperoxyl radical was followed. It was found that artepillin C exhibits an efficient radical-scavenging activity against cumylperoxyl radical in an aprotic medium. The absence of an effect of Sc3+ on the kHT values demonstrated that the hydrogen transfer from artepillin C to cumylperoxyl radical proceeds via one-step hydrogen atom transfer.

AB - Hydrogen transfer from artepillin C to cumylperoxyl radical was followed. It was found that artepillin C exhibits an efficient radical-scavenging activity against cumylperoxyl radical in an aprotic medium. The absence of an effect of Sc3+ on the kHT values demonstrated that the hydrogen transfer from artepillin C to cumylperoxyl radical proceeds via one-step hydrogen atom transfer.

UR - https://www.scopus.com/pages/publications/0141905846

U2 - 10.1039/b302098c

DO - 10.1039/b302098c

M3 - Article

AN - SCOPUS:0141905846

SN - 1477-0520

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EP - 1454

JO - Organic and Biomolecular Chemistry

JF - Organic and Biomolecular Chemistry

IS - 9

ER -

Efficient radical scavenging ability of artepillin C, a major component of Brazilian propolis, and the mechanism

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