Efficient delivery of siRNAs by a photothermal approach using plant flavonoid-inspired gold nanoshells

Hyukjin Lee; Eun Hye Jeong; Ji Hyun Ryu; Hansaem Jeong; Bora Jang; Ho Yeon Lee; Seonki Hong; Haeshin Lee

doi:10.1039/c4cc07155g

Efficient delivery of siRNAs by a photothermal approach using plant flavonoid-inspired gold nanoshells

Hyukjin Lee, Eun Hye Jeong, Ji Hyun Ryu, Hansaem Jeong, Bora Jang, Ho Yeon Lee, Seonki Hong, Haeshin Lee

Department of Pharmaceutical Sciences

Research output: Contribution to journal › Article › peer-review

21 Scopus citations

Abstract

Polymer gold nanoshells (PGNs) are prepared by a novel plant-inspired flavonoid surface modification method. The PGNs show dramatic photothermal properties, which can facilitate the endosomal escape and delivery of siRNA into the cytoplasm of cells. Efficient gene silencing has been achieved using siRNA immobilized PGNs, suggesting the potential applications of in vitro gene regulation by an external NIR stimulus.

Original language	English
Pages (from-to)	13388-13390
Number of pages	3
Journal	Chemical Communications
Volume	50
Issue number	87
DOIs	https://doi.org/10.1039/c4cc07155g
State	Published - 11 Nov 2014

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© the Partner Organisations 2014.

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title = "Efficient delivery of siRNAs by a photothermal approach using plant flavonoid-inspired gold nanoshells",

abstract = "Polymer gold nanoshells (PGNs) are prepared by a novel plant-inspired flavonoid surface modification method. The PGNs show dramatic photothermal properties, which can facilitate the endosomal escape and delivery of siRNA into the cytoplasm of cells. Efficient gene silencing has been achieved using siRNA immobilized PGNs, suggesting the potential applications of in vitro gene regulation by an external NIR stimulus.",

author = "Hyukjin Lee and Jeong, {Eun Hye} and Ryu, {Ji Hyun} and Hansaem Jeong and Bora Jang and Lee, {Ho Yeon} and Seonki Hong and Haeshin Lee",

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AU - Lee, Hyukjin

AU - Jeong, Eun Hye

AU - Ryu, Ji Hyun

AU - Jeong, Hansaem

AU - Jang, Bora

AU - Lee, Ho Yeon

AU - Hong, Seonki

AU - Lee, Haeshin

PY - 2014/11/11

Y1 - 2014/11/11

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AB - Polymer gold nanoshells (PGNs) are prepared by a novel plant-inspired flavonoid surface modification method. The PGNs show dramatic photothermal properties, which can facilitate the endosomal escape and delivery of siRNA into the cytoplasm of cells. Efficient gene silencing has been achieved using siRNA immobilized PGNs, suggesting the potential applications of in vitro gene regulation by an external NIR stimulus.

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JO - Chemical Communications

JF - Chemical Communications

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ER -

Efficient delivery of siRNAs by a photothermal approach using plant flavonoid-inspired gold nanoshells

Abstract

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