Efficient delivery of siRNAs by a photothermal approach using plant flavonoid-inspired gold nanoshells

Hyukjin Lee, Eun Hye Jeong, Ji Hyun Ryu, Hansaem Jeong, Bora Jang, Ho Yeon Lee, Seonki Hong, Haeshin Lee

Research output: Contribution to journalArticlepeer-review

20 Scopus citations

Abstract

Polymer gold nanoshells (PGNs) are prepared by a novel plant-inspired flavonoid surface modification method. The PGNs show dramatic photothermal properties, which can facilitate the endosomal escape and delivery of siRNA into the cytoplasm of cells. Efficient gene silencing has been achieved using siRNA immobilized PGNs, suggesting the potential applications of in vitro gene regulation by an external NIR stimulus. This journal is

Original languageEnglish
Pages (from-to)13388-13390
Number of pages3
JournalChemical Communications
Volume50
Issue number87
DOIs
StatePublished - 11 Nov 2014

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