Efficacy of polygonatum sibiricum on mild insomnia: A randomized placebo‐controlled trial

Eunji Ha; Haejin Hong; Tammy D. Kim; Gahae Hong; Suji Lee; Seunghee Kim; Nayeon Kim; Sang Duck Jeon; Chang Won Ahn; Hun Jung Kim; Young Jin Lee; Sujung Yoon; Geon Ha Kim; Jungyoon Kim

doi:10.3390/nu11081719

Efficacy of polygonatum sibiricum on mild insomnia: A randomized placebo‐controlled trial

Eunji Ha, Haejin Hong, Tammy D. Kim, Gahae Hong, Suji Lee, Seunghee Kim, Nayeon Kim, Sang Duck Jeon, Chang Won Ahn, Hun Jung Kim, Young Jin Lee, Sujung Yoon, Geon Ha Kim, Jungyoon Kim

Research output: Contribution to journal › Article › peer-review

13 Scopus citations

Abstract

Polygonatum sibiricum (PS) rhizome, which contains glyceryl‐1‐monolinoleate as its primary active component, has been shown to improve insomnia in animal models. Based on these findings, we aimed to investigate the safety and efficacy of PS rhizome extract in improving sleep quality in individuals with mild insomnia. Eighty individuals with mild insomnia were enrolled in a four‐week, randomized, double‐blind, placebo‐controlled trial of PS rhizome extract (500 mg/day, n = 40, PS group) or placebo (n = 40, placebo group). The primary outcome measure was change in total score on the Athens Insomnia Scale (AIS) to indicate sleep quality. The secondary outcome measures included change in actigraphy data and perfusion levels in the brain regions within the default mode network (DMN), which is known to play a key role in insomnia. The PS group showed greater improvement in the total AIS score with a significant increase in total sleep time, relative to the placebo group. In addition, significant group‐by‐visit interactions were observed in the perfusion level of the medial prefrontal cortex within the DMN. Findings of the current study provide first evidence that PS rhizome extract could be an effective natural ingredient for improving sleep in mild insomnia using a human model.

Original language	English
Article number	1719
Journal	Nutrients
Volume	11
Issue number	8
DOIs	https://doi.org/10.3390/nu11081719
State	Published - 2019

Bibliographical note

Funding Information:
Funding: This research was supported by the Brain Research Program through the National Research Foundation of Korea (NRF) funded by the Ministry of Science and ICT (2015M3C7A1028376), the Field‐oriented Support of Fire Fighting Technology Research and Development Program funded by the National Fire Agency of Korea (MPSS‐Fire Fighting Safety‐2016‐86), the ICT R&D program of the Institute for Information & Communications Technology Promotion of Korea (B0132‐15‐1001), and the Korea Institute of Planning and Evaluation for Technology in Food, Agriculture, Forestry (IPET) through the High Value‐Added Food Technology Development Program, funded by Ministry of Agriculture, Food and Rural Affairs (MAFRA)(116004‐02‐2‐HD020).

Publisher Copyright:
© 2019 by the authors. Licensee MDPI, Basel, Switzerland.

Keywords

Arterial spin labeling
Cerebral perfusion
Default mode network
Insomnia
Medial prefrontal cortex
Polygonatum
Randomized controlled trial

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@article{41886330d9134bf2b0a10ab2a9f551ab,

title = "Efficacy of polygonatum sibiricum on mild insomnia: A randomized placebo‐controlled trial",

abstract = "Polygonatum sibiricum (PS) rhizome, which contains glyceryl‐1‐monolinoleate as its primary active component, has been shown to improve insomnia in animal models. Based on these findings, we aimed to investigate the safety and efficacy of PS rhizome extract in improving sleep quality in individuals with mild insomnia. Eighty individuals with mild insomnia were enrolled in a four‐week, randomized, double‐blind, placebo‐controlled trial of PS rhizome extract (500 mg/day, n = 40, PS group) or placebo (n = 40, placebo group). The primary outcome measure was change in total score on the Athens Insomnia Scale (AIS) to indicate sleep quality. The secondary outcome measures included change in actigraphy data and perfusion levels in the brain regions within the default mode network (DMN), which is known to play a key role in insomnia. The PS group showed greater improvement in the total AIS score with a significant increase in total sleep time, relative to the placebo group. In addition, significant group‐by‐visit interactions were observed in the perfusion level of the medial prefrontal cortex within the DMN. Findings of the current study provide first evidence that PS rhizome extract could be an effective natural ingredient for improving sleep in mild insomnia using a human model.",

keywords = "Arterial spin labeling, Cerebral perfusion, Default mode network, Insomnia, Medial prefrontal cortex, Polygonatum, Randomized controlled trial",

author = "Eunji Ha and Haejin Hong and Kim, {Tammy D.} and Gahae Hong and Suji Lee and Seunghee Kim and Nayeon Kim and Jeon, {Sang Duck} and Ahn, {Chang Won} and Kim, {Hun Jung} and Lee, {Young Jin} and Sujung Yoon and Kim, {Geon Ha} and Jungyoon Kim",

note = "Funding Information: Funding: This research was supported by the Brain Research Program through the National Research Foundation of Korea (NRF) funded by the Ministry of Science and ICT (2015M3C7A1028376), the Field‐oriented Support of Fire Fighting Technology Research and Development Program funded by the National Fire Agency of Korea (MPSS‐Fire Fighting Safety‐2016‐86), the ICT R&D program of the Institute for Information & Communications Technology Promotion of Korea (B0132‐15‐1001), and the Korea Institute of Planning and Evaluation for Technology in Food, Agriculture, Forestry (IPET) through the High Value‐Added Food Technology Development Program, funded by Ministry of Agriculture, Food and Rural Affairs (MAFRA)(116004‐02‐2‐HD020). Publisher Copyright: {\textcopyright} 2019 by the authors. Licensee MDPI, Basel, Switzerland.",

year = "2019",

doi = "10.3390/nu11081719",

language = "English",

volume = "11",

journal = "Nutrients",

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T1 - Efficacy of polygonatum sibiricum on mild insomnia

T2 - A randomized placebo‐controlled trial

AU - Ha, Eunji

AU - Hong, Haejin

AU - Kim, Tammy D.

AU - Hong, Gahae

AU - Lee, Suji

AU - Kim, Seunghee

AU - Kim, Nayeon

AU - Jeon, Sang Duck

AU - Ahn, Chang Won

AU - Kim, Hun Jung

AU - Lee, Young Jin

AU - Yoon, Sujung

AU - Kim, Geon Ha

AU - Kim, Jungyoon

N1 - Funding Information: Funding: This research was supported by the Brain Research Program through the National Research Foundation of Korea (NRF) funded by the Ministry of Science and ICT (2015M3C7A1028376), the Field‐oriented Support of Fire Fighting Technology Research and Development Program funded by the National Fire Agency of Korea (MPSS‐Fire Fighting Safety‐2016‐86), the ICT R&D program of the Institute for Information & Communications Technology Promotion of Korea (B0132‐15‐1001), and the Korea Institute of Planning and Evaluation for Technology in Food, Agriculture, Forestry (IPET) through the High Value‐Added Food Technology Development Program, funded by Ministry of Agriculture, Food and Rural Affairs (MAFRA)(116004‐02‐2‐HD020). Publisher Copyright: © 2019 by the authors. Licensee MDPI, Basel, Switzerland.

PY - 2019

Y1 - 2019

N2 - Polygonatum sibiricum (PS) rhizome, which contains glyceryl‐1‐monolinoleate as its primary active component, has been shown to improve insomnia in animal models. Based on these findings, we aimed to investigate the safety and efficacy of PS rhizome extract in improving sleep quality in individuals with mild insomnia. Eighty individuals with mild insomnia were enrolled in a four‐week, randomized, double‐blind, placebo‐controlled trial of PS rhizome extract (500 mg/day, n = 40, PS group) or placebo (n = 40, placebo group). The primary outcome measure was change in total score on the Athens Insomnia Scale (AIS) to indicate sleep quality. The secondary outcome measures included change in actigraphy data and perfusion levels in the brain regions within the default mode network (DMN), which is known to play a key role in insomnia. The PS group showed greater improvement in the total AIS score with a significant increase in total sleep time, relative to the placebo group. In addition, significant group‐by‐visit interactions were observed in the perfusion level of the medial prefrontal cortex within the DMN. Findings of the current study provide first evidence that PS rhizome extract could be an effective natural ingredient for improving sleep in mild insomnia using a human model.

AB - Polygonatum sibiricum (PS) rhizome, which contains glyceryl‐1‐monolinoleate as its primary active component, has been shown to improve insomnia in animal models. Based on these findings, we aimed to investigate the safety and efficacy of PS rhizome extract in improving sleep quality in individuals with mild insomnia. Eighty individuals with mild insomnia were enrolled in a four‐week, randomized, double‐blind, placebo‐controlled trial of PS rhizome extract (500 mg/day, n = 40, PS group) or placebo (n = 40, placebo group). The primary outcome measure was change in total score on the Athens Insomnia Scale (AIS) to indicate sleep quality. The secondary outcome measures included change in actigraphy data and perfusion levels in the brain regions within the default mode network (DMN), which is known to play a key role in insomnia. The PS group showed greater improvement in the total AIS score with a significant increase in total sleep time, relative to the placebo group. In addition, significant group‐by‐visit interactions were observed in the perfusion level of the medial prefrontal cortex within the DMN. Findings of the current study provide first evidence that PS rhizome extract could be an effective natural ingredient for improving sleep in mild insomnia using a human model.

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KW - Default mode network

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KW - Medial prefrontal cortex

KW - Polygonatum

KW - Randomized controlled trial

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JO - Nutrients

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M1 - 1719

ER -

Efficacy of polygonatum sibiricum on mild insomnia: A randomized placebo‐controlled trial

Abstract

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Keywords

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