Efficacy of polygonatum sibiricum on mild insomnia: A randomized placebo‐controlled trial

Eunji Ha, Haejin Hong, Tammy D. Kim, Gahae Hong, Suji Lee, Seunghee Kim, Nayeon Kim, Sang Duck Jeon, Chang Won Ahn, Hun Jung Kim, Young Jin Lee, Sujung Yoon, Geon Ha Kim, Jungyoon Kim

Research output: Contribution to journalArticlepeer-review

12 Scopus citations


Polygonatum sibiricum (PS) rhizome, which contains glyceryl‐1‐monolinoleate as its primary active component, has been shown to improve insomnia in animal models. Based on these findings, we aimed to investigate the safety and efficacy of PS rhizome extract in improving sleep quality in individuals with mild insomnia. Eighty individuals with mild insomnia were enrolled in a four‐week, randomized, double‐blind, placebo‐controlled trial of PS rhizome extract (500 mg/day, n = 40, PS group) or placebo (n = 40, placebo group). The primary outcome measure was change in total score on the Athens Insomnia Scale (AIS) to indicate sleep quality. The secondary outcome measures included change in actigraphy data and perfusion levels in the brain regions within the default mode network (DMN), which is known to play a key role in insomnia. The PS group showed greater improvement in the total AIS score with a significant increase in total sleep time, relative to the placebo group. In addition, significant group‐by‐visit interactions were observed in the perfusion level of the medial prefrontal cortex within the DMN. Findings of the current study provide first evidence that PS rhizome extract could be an effective natural ingredient for improving sleep in mild insomnia using a human model.

Original languageEnglish
Article number1719
Issue number8
StatePublished - 2019

Bibliographical note

Funding Information:
Funding: This research was supported by the Brain Research Program through the National Research Foundation of Korea (NRF) funded by the Ministry of Science and ICT (2015M3C7A1028376), the Field‐oriented Support of Fire Fighting Technology Research and Development Program funded by the National Fire Agency of Korea (MPSS‐Fire Fighting Safety‐2016‐86), the ICT R&D program of the Institute for Information & Communications Technology Promotion of Korea (B0132‐15‐1001), and the Korea Institute of Planning and Evaluation for Technology in Food, Agriculture, Forestry (IPET) through the High Value‐Added Food Technology Development Program, funded by Ministry of Agriculture, Food and Rural Affairs (MAFRA)(116004‐02‐2‐HD020).

Publisher Copyright:
© 2019 by the authors. Licensee MDPI, Basel, Switzerland.


  • Arterial spin labeling
  • Cerebral perfusion
  • Default mode network
  • Insomnia
  • Medial prefrontal cortex
  • Polygonatum
  • Randomized controlled trial


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