Efficacy of percutaneous ethanol injection therapy in Korean with hepatocellular carcinoma

Hyoun Woo Kang, Yoon Jun Kim, Kang Mo Kim, Jung Mook Kang, Su Hwan Kim, Jin Hyun Kim, Won Jae Yoon, Jung Hwan Yoon, Yong Bum Yoon, Hyo Suk Lee

Research output: Contribution to journalArticlepeer-review

3 Scopus citations


BACKGROUND/AIMS: Percutaneous ethanol injection therapy (PEIT) is widely used for the treatment of hepatocellular carcinoma (HCC). However, its long-term therapeutic efficacy is not verified in Korea, one of hepatitis B virus (HBV) endemic areas. Thus, this study was to assess its efficacy and prognostic factors affecting tumor-free survival following PEIT in Korean HCC patients. METHODS: From 1997 to 1999, 100 consecutive patients who had 1 to 3 HCC nodules of maximum diameter less than 3 cm and underwent PEIT were enrolled. Therapeutic efficacy, overall and tumor-free survival rates were assessed during follow-up periods. RESULTS: In 83 patients, HCC nodules were completely ablated by PEIT. The cumulative 1, 2, and 3 year overall survival rates were 98%, 96%, and 88%, respectively. The cumulative 1, 2, and 3 year tumor-free survival rates were 73%, 50%, and 37%, respectively. Larger tumors (>or= 2 cm) were associated with a higher local recurrence rate. CONCLUSIONS: These results demonstrate that PEIT is therapeutically useful in patients with HCC less than 4 in number and less than 3 cm in diameter. However, since multiple or large tumors are associated with low tumor-free survival or high local recurrence rates, PEIT for these tumors and the subsequent post-treatment follow-up should be performed carefully.

Original languageEnglish
Pages (from-to)502-509
Number of pages8
JournalThe Korean journal of gastroenterology = Taehan Sohwagi Hakhoe chi
Issue number6
StatePublished - Dec 2003


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