Efficacy and safety of kudzu flower–mandarin peel on hot flashes and bone markers in women during the menopausal transition: A randomized controlled trial

Ji Eon Kim; Hyeyun Jeong; Soohee Hur; Junho Lee; Oran Kwon

doi:10.3390/nu12113237

Efficacy and safety of kudzu flower–mandarin peel on hot flashes and bone markers in women during the menopausal transition: A randomized controlled trial

Ji Eon Kim, Hyeyun Jeong, Soohee Hur, Junho Lee, Oran Kwon

Department of Nutritional Science & Food Management

Research output: Contribution to journal › Article › peer-review

6 Scopus citations

Abstract

This randomized controlled study aimed to assess the efficacy and safety of an extract mixture of kudzu flower and mandarin peel (KM) on hot flashes (HFs) and markers of bone turnover in women during the menopausal transition. Healthy women aged 45–60 years with the menopausal HFs were randomly assigned in a 1:1 ratio to either KM (1150 mg/day) or placebo arms for 12 weeks (n = 84). The intent-to-treat analysis found that compared with the placebo, the KM significantly attenuated HF scores (p = 0.041) and HF severities (p < 0.001), with a mean difference from baseline to week 12. The KM also improved bone turnover markers, showing a significant reduction in bone resorption CTx (p = 0.027) and a tendency of increasing bone formation OC relative to the placebo. No serious adverse events and hormonal changes were observed in both groups. These findings suggest that KM consumption may improve the quality of life in ways that are important to symptomatic menopausal women.

Original language	English
Article number	3237
Pages (from-to)	1-13
Number of pages	13
Journal	Nutrients
Volume	12
Issue number	11
DOIs	https://doi.org/10.3390/nu12113237
State	Published - Nov 2020

Bibliographical note

Funding Information:
Funding: This research was funded by the Bio-Synergy Research Project of the Ministry of Science and ICT through the National Research Foundation, grant number NRF-2012M3A9C4048761, and the LG Household and Healthcare.

Funding Information:
This research was funded by the Bio-Synergy Research Project of the Ministry of Science and ICT through the National Research Foundation, grant number NRF-2012M3A9C4048761, and the LG Household and Healthcare. We thank the 84 women who participated in this study, and Hanaro Medical Foundation, and Dong-A Radiology Clinics for contributing to the safety monitoring over the entire study period. We also thank our study physicians, Bumjo Oh and KyuRi Hwang, for their clinical oversight of the women in this study.

Publisher Copyright:
© 2020 by the authors. Licensee MDPI, Basel, Switzerland.

Keywords

Bone resorption
Citrus unshiu
Hot flash
Menopause
Pueraria thomsonii

Access to Document

10.3390/nu12113237

Cite this

@article{6d2b59bfc82f4f468922ecb022235867,

title = "Efficacy and safety of kudzu flower–mandarin peel on hot flashes and bone markers in women during the menopausal transition: A randomized controlled trial",

abstract = "This randomized controlled study aimed to assess the efficacy and safety of an extract mixture of kudzu flower and mandarin peel (KM) on hot flashes (HFs) and markers of bone turnover in women during the menopausal transition. Healthy women aged 45–60 years with the menopausal HFs were randomly assigned in a 1:1 ratio to either KM (1150 mg/day) or placebo arms for 12 weeks (n = 84). The intent-to-treat analysis found that compared with the placebo, the KM significantly attenuated HF scores (p = 0.041) and HF severities (p < 0.001), with a mean difference from baseline to week 12. The KM also improved bone turnover markers, showing a significant reduction in bone resorption CTx (p = 0.027) and a tendency of increasing bone formation OC relative to the placebo. No serious adverse events and hormonal changes were observed in both groups. These findings suggest that KM consumption may improve the quality of life in ways that are important to symptomatic menopausal women.",

keywords = "Bone resorption, Citrus unshiu, Hot flash, Menopause, Pueraria thomsonii",

author = "Kim, {Ji Eon} and Hyeyun Jeong and Soohee Hur and Junho Lee and Oran Kwon",

note = "Funding Information: Funding: This research was funded by the Bio-Synergy Research Project of the Ministry of Science and ICT through the National Research Foundation, grant number NRF-2012M3A9C4048761, and the LG Household and Healthcare. Funding Information: This research was funded by the Bio-Synergy Research Project of the Ministry of Science and ICT through the National Research Foundation, grant number NRF-2012M3A9C4048761, and the LG Household and Healthcare. We thank the 84 women who participated in this study, and Hanaro Medical Foundation, and Dong-A Radiology Clinics for contributing to the safety monitoring over the entire study period. We also thank our study physicians, Bumjo Oh and KyuRi Hwang, for their clinical oversight of the women in this study. Publisher Copyright: {\textcopyright} 2020 by the authors. Licensee MDPI, Basel, Switzerland.",

year = "2020",

month = nov,

doi = "10.3390/nu12113237",

language = "English",

volume = "12",

pages = "1--13",

journal = "Nutrients",

issn = "2072-6643",

publisher = "Multidisciplinary Digital Publishing Institute (MDPI)",

number = "11",

}

TY - JOUR

T1 - Efficacy and safety of kudzu flower–mandarin peel on hot flashes and bone markers in women during the menopausal transition

T2 - A randomized controlled trial

AU - Kim, Ji Eon

AU - Jeong, Hyeyun

AU - Hur, Soohee

AU - Lee, Junho

AU - Kwon, Oran

N1 - Funding Information: Funding: This research was funded by the Bio-Synergy Research Project of the Ministry of Science and ICT through the National Research Foundation, grant number NRF-2012M3A9C4048761, and the LG Household and Healthcare. Funding Information: This research was funded by the Bio-Synergy Research Project of the Ministry of Science and ICT through the National Research Foundation, grant number NRF-2012M3A9C4048761, and the LG Household and Healthcare. We thank the 84 women who participated in this study, and Hanaro Medical Foundation, and Dong-A Radiology Clinics for contributing to the safety monitoring over the entire study period. We also thank our study physicians, Bumjo Oh and KyuRi Hwang, for their clinical oversight of the women in this study. Publisher Copyright: © 2020 by the authors. Licensee MDPI, Basel, Switzerland.

PY - 2020/11

Y1 - 2020/11

N2 - This randomized controlled study aimed to assess the efficacy and safety of an extract mixture of kudzu flower and mandarin peel (KM) on hot flashes (HFs) and markers of bone turnover in women during the menopausal transition. Healthy women aged 45–60 years with the menopausal HFs were randomly assigned in a 1:1 ratio to either KM (1150 mg/day) or placebo arms for 12 weeks (n = 84). The intent-to-treat analysis found that compared with the placebo, the KM significantly attenuated HF scores (p = 0.041) and HF severities (p < 0.001), with a mean difference from baseline to week 12. The KM also improved bone turnover markers, showing a significant reduction in bone resorption CTx (p = 0.027) and a tendency of increasing bone formation OC relative to the placebo. No serious adverse events and hormonal changes were observed in both groups. These findings suggest that KM consumption may improve the quality of life in ways that are important to symptomatic menopausal women.

AB - This randomized controlled study aimed to assess the efficacy and safety of an extract mixture of kudzu flower and mandarin peel (KM) on hot flashes (HFs) and markers of bone turnover in women during the menopausal transition. Healthy women aged 45–60 years with the menopausal HFs were randomly assigned in a 1:1 ratio to either KM (1150 mg/day) or placebo arms for 12 weeks (n = 84). The intent-to-treat analysis found that compared with the placebo, the KM significantly attenuated HF scores (p = 0.041) and HF severities (p < 0.001), with a mean difference from baseline to week 12. The KM also improved bone turnover markers, showing a significant reduction in bone resorption CTx (p = 0.027) and a tendency of increasing bone formation OC relative to the placebo. No serious adverse events and hormonal changes were observed in both groups. These findings suggest that KM consumption may improve the quality of life in ways that are important to symptomatic menopausal women.

KW - Bone resorption

KW - Citrus unshiu

KW - Hot flash

KW - Menopause

KW - Pueraria thomsonii

UR - http://www.scopus.com/inward/record.url?scp=85094139052&partnerID=8YFLogxK

U2 - 10.3390/nu12113237

DO - 10.3390/nu12113237

M3 - Article

C2 - 33105861

AN - SCOPUS:85094139052

SN - 2072-6643

VL - 12

SP - 1

EP - 13

JO - Nutrients

JF - Nutrients

IS - 11

M1 - 3237

ER -

Efficacy and safety of kudzu flower–mandarin peel on hot flashes and bone markers in women during the menopausal transition: A randomized controlled trial

Abstract

Bibliographical note

Keywords

Access to Document

Fingerprint

Cite this