Efficacy and safety of kudzu flower–mandarin peel on hot flashes and bone markers in women during the menopausal transition: A randomized controlled trial

Ji Eon Kim, Hyeyun Jeong, Soohee Hur, Junho Lee, Oran Kwon

Research output: Contribution to journalArticlepeer-review

1 Scopus citations

Abstract

This randomized controlled study aimed to assess the efficacy and safety of an extract mixture of kudzu flower and mandarin peel (KM) on hot flashes (HFs) and markers of bone turnover in women during the menopausal transition. Healthy women aged 45–60 years with the menopausal HFs were randomly assigned in a 1:1 ratio to either KM (1150 mg/day) or placebo arms for 12 weeks (n = 84). The intent-to-treat analysis found that compared with the placebo, the KM significantly attenuated HF scores (p = 0.041) and HF severities (p < 0.001), with a mean difference from baseline to week 12. The KM also improved bone turnover markers, showing a significant reduction in bone resorption CTx (p = 0.027) and a tendency of increasing bone formation OC relative to the placebo. No serious adverse events and hormonal changes were observed in both groups. These findings suggest that KM consumption may improve the quality of life in ways that are important to symptomatic menopausal women.

Original languageEnglish
Article number3237
Pages (from-to)1-13
Number of pages13
JournalNutrients
Volume12
Issue number11
DOIs
StatePublished - Nov 2020

Keywords

  • Bone resorption
  • Citrus unshiu
  • Hot flash
  • Menopause
  • Pueraria thomsonii

Fingerprint

Dive into the research topics of 'Efficacy and safety of kudzu flower–mandarin peel on hot flashes and bone markers in women during the menopausal transition: A randomized controlled trial'. Together they form a unique fingerprint.

Cite this