Efferocytosis and enhanced FPR2 expression following apoptotic cell instillation attenuate radiation-induced lung inflammation and fibrosis

Sang Yeon Kim, Jin Mo Kim, Son Ro Lee, Hyun Jin Kim, Jae Hee Lee, Ho Lim Choi, Yoon Jin Lee, Yun Sil Lee, Jaeho Cho

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4 Scopus citations


Lung inflammation and fibrosis are common side effects of radiotherapy that can lead to serious reduction in the quality of life of patients. However, no effective treatment is available, and the mechanisms underlying its pathophysiology are poorly understood. Irradiation increases formyl peptide receptor 2 (FPR2) expression in lung tissue, and FPR2 agonists are known to promote the uptake of apoptosis cells, referred to as efferocytosis that is a hallmark of the resolution of inflammation. Herein, in a mouse model of radiation-induced lung injury (RILI), efferocytosis was induced by injecting apoptotic cells into the lung through the trachea, and its correlation with FPR expression and the effect of efferocytosis and FPR expression on RILI were assessed. Interestingly, when apoptotic cells were injected into the lung, the radiation-induced increase in FPR2 expression was further amplified. In the mouse model of RILI, apoptotic cell instillation reduced the volume of the damaged lung and prevented the decrease in lung function. Additionally, the expression of inflammatory cytokines, fibrosis-related markers, and oxidative stress-related markers was reduced by apoptotic cell instillation. Co-administration of apoptotic Jurkat cells and WRW4, the FPR2 antagonist, reversed these effects. These findings suggest that efferocytosis induced by apoptotic cell instillation and enhanced FPR2 expression attenuate RILI, thereby alleviating lung inflammation and fibrosis.

Original languageEnglish
Pages (from-to)38-44
Number of pages7
JournalBiochemical and Biophysical Research Communications
StatePublished - 23 Apr 2022

Bibliographical note

Funding Information:
This work was supported by grant from the National Research Foundation of Korea (NRF) [grant numbers NRF-2019R1A2C2086448 , NRF-2020M2D9A2093976 and 2021R1I1A1A01044625 ].

Publisher Copyright:
© 2022 The Authors


  • Efferocytosis
  • Formyl peptide receptor 2
  • Irradiation
  • Lung fibrosis
  • Lung inflammation


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