Effects of single or repeated silymarin administration on pharmacokinetics of risperidone and its major metabolite, 9-hydroxyrisperidone in rats

Hwa Jeong Lee, Kyoung Sin Lee, Song Wha Chae, Joon Hee Park, Jung Hyun Park, Jong Min Choi, Sandy Rhie

Research output: Contribution to journalArticlepeer-review

8 Scopus citations

Abstract

1. The interactions between herbal dietary supplements and therapeutic drugs have emerged as an important issue and P-glycoprotein (P-gp) has been reported as one of the significant factors of these interactions. 2. The objective of this article is to examine the effects of single and repeated administrations of silymarin on pharmacokinetics of a P-gp substrate, risperidone, and its major metabolite, 9-hydroxyrisperidone, in rats. 3. To determine the plasma levels of risperidone and 9-hydroxyrisperidone in rats, a HPLC method was developed using a liquid-liquid acid back extraction. When risperidone (6 mg/kg) was co-administered with silymarin (40 mg/kg) to rats orally, the Cmax of 9-hydroxyrisperidone was significantly increased to1.3-fold (p < 0.05), while the other pharmacokinetic parameters did not show any significant differences. Expanding the experiment where rats were repeatedly administered with silymarin for 5 days prior to giving risperidone, the Cmax of risperidone and 9-hydroxyrisperidone were significantly increased to 2.4-fold (p < 0.001) and 1.7-fold (p < 0.001), respectively, and the AUC0-t, as well to 1.7-fold (p < 0.05) and 2.1-fold (p < 0.01), respectively. 4. The repeated exposures of silymarin, compared to single administration of silymarin, increased oral bioavailability and affected the pharmacokinetics of risperidone and 9-hydroxyrisperidone, by inhibiting P-gp.

Original languageEnglish
Pages (from-to)303-310
Number of pages8
JournalXenobiotica
Volume43
Issue number3
DOIs
StatePublished - Mar 2013

Keywords

  • 9-hydroxyrisperidone
  • Bioavailability
  • Drug interactions
  • P-glycoprotein
  • Risperidone
  • Silymarin

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