Effects of protostane-type triterpenoids on the 5-HT3A receptor-mediated ion current in Xenopus oocytes

Jun Ho Lee, Yoo Jin Lee, Seok Woo Kang, Yangseok Kim, Minkyu Shin, Moochang Hong, Eun Kyoung Seo, Sung Hoon Kim, Seung Yeol Nah, Hyunsu Bae

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15 Scopus citations


Alisol derivatives are unique protostane-type triterpenoid compounds that are isolated from Alismatis rhizoma, which is a well-known traditional medicine in East Asia. In the present study, we investigated the effects of protostane-type triterpenoids (AA, Alisol A; AB, Alisol B; AB-ac, Alisol B 23-acetate; AC-ac, Alisol C 23-aceteate) on 5-HT-induced currents mediated by the human 5-HT3A receptor expressed in Xenopus laevis oocytes. Co-treatment with triterpenoids regulated the 5-HT-induced inward peak current in a concentration-dependent and reversible manner. In addition, regulation of I5-HT by triterpenoids occurred in a non-competitive manner. Taken together, these results indicate that triterpenoids may regulate the 5-HT3A receptors that are expressed in Xenopus oocytes. Furthermore, this regulation of the ligand-gated ion channel activity by triterpenoids may be one of the pharmacological actions of Alismatis rhizoma.

Original languageEnglish
Pages (from-to)20-27
Number of pages8
JournalBrain Research
StatePublished - 17 May 2010

Bibliographical note

Funding Information:
This work was supported by a grant from the Kyung-Hee University Post-Doctoral fellowship in 2009 ( KHU-20090503 )


  • 5-HTA receptor
  • Triterpenoid
  • Two-electrode voltage clamp


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