Effects of lactobacillus plantarum Q180 on postprandial lipid levels and intestinal environment: A double-blind, randomized, placebo-controlled, parallel trial

Ye Eun Park, Min Seo Kim, Kyung Won Shim, You Il Kim, Jaeryang Chu, Byoung Kook Kim, In Suk Choi, Ji Yeon Kim

Research output: Contribution to journalArticlepeer-review

11 Scopus citations

Abstract

Probiotics can improve the intestinal environment by enhancing beneficial bacteria to potentially regulate lipid levels; however, the underlying mechanisms remain unclear. The aim of this study was to investigate the effect of Lactobacillus plantarum Q180 (LPQ180) on postprandial lipid metabolism and the intestinal microbiome environment from a clinical perspective. A double-blind, randomized, placebo-controlled study was conducted including 70 participants of both sexes, 20 years of age and older, with healthy blood triacylglyceride (TG) levels below 200 mg/dL. Treatment with LPQ180 for 12 weeks significantly decreased LDL-cholesterol (p = 0.042) and apolipoprotein (Apo)B-100 (p = 0.003) levels, and decreased postprandial maximum concentrations (Cmax) and areas under the curve (AUC) of TG, chylomicron TG, ApoB-48, and ApoB-100. LPQ180 treatment significantly decreased total indole and phenol levels (p = 0.019). In addition, there was a negative correlation between baseline microbiota abundance and lipid marker change, which was negatively correlated with metabolites. This study suggests that LPQ180 might be developed as a functional ingredient to help maintain healthy postprandial lipid levels through modulating gut environment.

Original languageEnglish
Article number255
JournalNutrients
Volume12
Issue number1
DOIs
StatePublished - Jan 2020

Keywords

  • Correlation
  • Intestinal microbiota
  • Intestinal microbiota metabolites
  • LPQ180
  • Lipid mechanism
  • Postprandial lipids
  • Probiotics

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