Effects of Korean red ginseng on human gray matter volume and cognitive function: A voxel-based morphometry study

Eun Namgung, Jungyoon Kim, Hyeonseok Jeong, Gahae Hong, Myeongju Kim, Rye Young Kim, Shinhye Kim, In Kyoon Lyoo

Research output: Contribution to journalArticlepeer-review

10 Scopus citations

Abstract

Objective: We aimed to investigate the effects of Korean red ginseng (KRG) supplementation on gray matter volume of the human brain which could be related to cognitive enhancing effects of KRG. Methods: In this randomized, double-blind, placebo-controlled study, 51 healthy individuals were assigned to receive either KRG (1000 mg/day, n = 26) or placebo (n = 25) for 8 weeks. Gray matter volume of the whole brain was measured using voxel-based morphometry based on high-resolution T1-weighted magnetic resonance images acquired at baseline and week 8. The standardized composite cognitive scores of executive function, attention, and memory were also evaluated at baseline and week 8. Changes in gray matter volume as well as the composite cognitive scores were compared between the KRG and placebo groups. Results: Following 8 weeks of KRG supplementation, the gray matter volume of the left parahippocampal gyrus increased significantly in the KRG group, relative to the placebo group (p for interaction < 0.001). The KRG group also showed greater magnitude of enhancement in the composite cognitive scores relative to the placebo group (p for interaction = 0.03). Conclusions: Gray matter volume increase in the parahippocampus may be a key neural change as induced by KRG supplementation, which could be associated with cognitive enhancement.

Original languageEnglish
Article numbere2767
JournalHuman Psychopharmacology
Volume36
Issue number2
DOIs
StatePublished - Mar 2021

Bibliographical note

Funding Information:
This research was supported by the Field‐oriented Support of Fire Fighting Technology Research and Development Program funded by the National Fire Agency to J.K. (MPSS‐Fire Fighting Safety‐2016‐86) as well as by the National Research Foundation of Korea (NRF‐2020R1A6A1A03043528 and NRF‐2020M3E5D9080555) and the Korean Society of Ginseng to I.K.L.

Publisher Copyright:
© 2020 John Wiley & Sons Ltd.

Keywords

  • Korean red ginseng
  • brain magnetic resonance imaging
  • cognition
  • gray matter
  • voxel-based morphometry

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