In this study, we investigated the effects of Korean red ginseng water extract (KRGE) on hepatic lipid accumulation in HepG2 cells. KRGE decreased hepatic triglyceride and cholesterol levels. Further, KRGE suppressed expression of fatty acid synthase (FAS) and 3-hydroxy-3-methyl glutaryl coenzyme A (HMG-CoA) reductase. These results suggest that KRGE may reduce hepatic lipid accumulation by inhibition of FAS and HMG-CoA reductase expression in HepG2 cells.
- 3-hydroxy-3-methyl glutaryl coenzyme a (HMG-CoA) reductase
- Fatty acid synthase (FAS)
- Hepatic lipid accumulation
- HepG2 cells
- Korean red ginseng water extract (KRGE)