Effects of KCNMB2 gene polymorphisms on ritodrine therapy outcomes in women with preterm labor

Ha Young Yoon, Jin Young Park, Jeong Yee, Han Sung Hwang, Jee Eun Chung, Kyung Eun Lee, Young Ju Kim, Hye Sun Gwak

Research output: Contribution to journalArticlepeer-review

Abstract

Objective The present prospective follow-up study aimed to evaluate the effects of KCNMB2 gene polymorphisms on ritodrine efficacy and adverse drug events (ADEs) in patients with preterm labor. Methods A total of 163 preterm labor patients were included in this single-center study. Nine single nucleotide polymorphisms (SNPs) in the KCNMB2 gene (rs10936979, rs7624046, rs7429015, rs7625907, rs6443559, rs9839376, rs9637454, rs11918114, and rs1382045) were assessed. The primary endpoint was time to delivery, and the secondary endpoint was ritodrine-induced ADEs. Results Patients with variant homozygotes of two SNPs (rs7624046 and rs9839376), which were in linkage disequilibrium, showed 2.06 [95% confidence interval (CI), 1.14-3.73] and 2.68 (95% CI, 1.16-6.20) times the hazard of time to delivery compared to wild-type allele carriers, respectively. Among demographic characteristics, gestational age at start of drug therapy and modified Bishop score were significant factors for time to delivery. Regarding safety outcomes, patients with variant homozygotes of rs7625907 had fewer ADEs compared to those with other genotypes (odds ratio, 0.32; 95% CI, 0.13-0.83). Conclusion This pharmacogenomic study suggests that ritodrine efficacy and ADEs are associated with KCNMB2 gene polymorphisms in patients with preterm labor.

Original languageEnglish
Pages (from-to)124-130
Number of pages7
JournalPharmacogenetics and Genomics
DOIs
StateAccepted/In press - 2020

Keywords

  • adverse drug event
  • KCNMB2
  • preterm labor
  • ritodrine
  • single nucleotide polymorphism
  • time to delivery

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