Effects of Dietary Fat to Carbohydrate Ratio on Obesity Risk Depending on Genotypes of Circadian Genes

Jinyoung Shon, Yerim Han, Yoonjung Park

Research output: Contribution to journalArticlepeer-review

6 Scopus citations


Although the impacts of macronutrients and the circadian clock on obesity have been reported, the interactions between macronutrient distribution and circadian genes are unclear. The aim of this study was to explore macronutrient intake patterns in the Korean population and associations between the patterns and circadian gene variants and obesity. After applying the criteria, 5343 subjects (51.6% male, mean age 49.4 ± 7.3 years) from the Korean Genome and Epidemiology Study data and nine variants in seven circadian genes were analyzed. We defined macronutrient intake patterns by tertiles of the fat to carbohydrate ratio (FC). The very low FC (VLFC) was associated with a higher risk of obesity than the optimal FC (OFC). After stratification by the genotypes of nine variants, the obesity risk according to the patterns differed by the variants. In the female VLFC, the major homozygous allele of CLOCK rs11932595 and CRY1 rs3741892 had a higher abdominal obesity risk than those in the OFC. The GG genotype of PER2 rs2304672 in the VLFC showed greater risks for obesity and abdominal obesity. In conclusion, these findings suggest that macronutrient intake patterns were associated with obesity susceptibility, and the associations were different depending on the circadian clock genotypes of the CLOCK, PER2, and CRY1 loci.

Original languageEnglish
Article number478
Issue number3
StatePublished - 1 Feb 2022

Bibliographical note

Funding Information:
Acknowledgments: This study was conducted with bioresources from the National Biobank of Korea, the Korea Disease Control and Prevention Agency, and Korea (KBN-2021-035). J.S. was supported by NRF funded by the Ministry of Education (2020R1A6A3A13075729) and Hyundai Motor Chung Mong-Koo Foundation. Y.H. was supported by Brain Korea Four Project (Education Research Center for 4IR-Based Health Care).

Funding Information:
Funding: This study was supported by Basic Science Research Programs through the National Research Foundation (NRF) funded by the Korean government (2021R1A2C2012578).

Publisher Copyright:
© 2022 by the authors. Licensee MDPI, Basel, Switzerland.


  • Circadian gene
  • Genetic variant
  • Macronutrient distribution
  • Obesity
  • Single nucleotide polymorphisms (SNPs)


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