Effects of cocaine on tyrosine hydroxylase activity in brain areas from SHR and WKY

B. Hoskins, S. K. Oh, Y. T. Tseng, R. W. Rockhold, I. K. Ho

Research output: Contribution to journalArticlepeer-review

5 Scopus citations

Abstract

Basal tyrosine hydroxylase activity was the same in the nuclei accumbens and hypothalami of WKY and SHR. Basal striatal enzyme activity was lower in SHR than in WKY. Acute and subacute cocaine administration altered enzyme activity only in striata and nuclei accumbens of WKY. The central dopaminergic system of SHR appears to be less active and less sensitive to cocaine than that of WKY.

Original languageEnglish
Pages (from-to)639-641
Number of pages3
JournalBrain Research Bulletin
Volume25
Issue number4
DOIs
StatePublished - Oct 1990

Keywords

  • Cocaine
  • Spontaneously hypertensive rats
  • Tyrosine hydroxylase in brain
  • Wistar-Kyoto rats

Fingerprint

Dive into the research topics of 'Effects of cocaine on tyrosine hydroxylase activity in brain areas from SHR and WKY'. Together they form a unique fingerprint.

Cite this