Effects of chitooligosaccharide lactate salt on activity of acetaldehyde dehydrogenase

Si Young Cho, Jun Won Yun, Pil Joon Park, Jong Hee Sohn, Dae Bang Seo, Kyung Min Lim, Wan Gi Kim, Sang Jun Lee

Research output: Contribution to journalArticlepeer-review

3 Scopus citations

Abstract

Chitooligosaccharides (COS), a kind of oligosaccharide made from chitin or chitosan, have been used a popular remedy for hangovers. In this study we investigated the in vitro effect of COS lactate salt on ethanol-induced cytotoxicity and the in vivo effect of short-term COS lactate salt feeding on ethanol-induced hangover. Pretreatment of HepG2 cells with COS lactate salt significantly reduced ethanol-induced cytotoxicity and suppressed generation of reactive oxygen species. In addition, COS lactate salt dose-dependently increased acetaldehyde dehydrogenase (ALDH) activity in vitro and reversed the ALDH inhibition induced by daidzin. Furthermore, oral administration of COS lactate salt (200 mg/kg) for 5 days significantly decreased the blood levels of alcohol and acetaldehyde in ethanol-treated mice. It was also demonstrated that hepatic mitochondrial ALDH activity was significantly increased in COS lactate salt-treated mice. Taken together, these findings indicate that COS lactate salt may have efficacy for the management of alcoholic hangovers.

Original languageEnglish
Pages (from-to)1061-1068
Number of pages8
JournalJournal of Medicinal Food
Volume13
Issue number5
DOIs
StatePublished - 2010

Keywords

  • acetaldehyde dehydrogenase
  • chitooligosaccharide lactate salt
  • cytotoxicity
  • ethanol
  • hangover

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