Effects of cerebrovascular disease and amyloid beta burden on cognition in subjects with subcortical vascular cognitive impairment

Jae Hyun Park; Sang Won Seo; Changsoo Kim; Sook Hui Kim; Geon Ha Kim; Sung Tae Kim; Seun Jeon; Jong Min Lee; Seung Jun Oh; Jae Seung Kim; Yearn Seong Choe; Kyung Han Lee; Ji Soo Shin; Chi Hun Kim; Young Noh; Hanna Cho; Cindy W. Yoon; Hee Jin Kim; Byoung Seok Ye; Michael Ewers; Michael W. Weiner; Jae Hong Lee; David J. Werring; Duk L. Na

doi:10.1016/j.neurobiolaging.2013.06.026

Effects of cerebrovascular disease and amyloid beta burden on cognition in subjects with subcortical vascular cognitive impairment

Jae Hyun Park, Sang Won Seo, Changsoo Kim, Sook Hui Kim, Geon Ha Kim, Sung Tae Kim, Seun Jeon, Jong Min Lee, Seung Jun Oh, Jae Seung Kim, Yearn Seong Choe, Kyung Han Lee, Ji Soo Shin, Chi Hun Kim, Young Noh, Hanna Cho, Cindy W. Yoon, Hee Jin Kim, Byoung Seok Ye, Michael EwersMichael W. Weiner, Jae Hong Lee, David J. Werring, Duk L. Na

Department of Neurology

Research output: Contribution to journal › Article › peer-review

72 Scopus citations

Abstract

Cerebrovascular disease (CVD) and amyloid burden are the most frequent pathologies in subjects with cognitive impairment. However, the relationship between CVD, amyloid burden, and cognition are largely unknown. We aimed to evaluate whether CVD (lacunes, white matter hyperintensities, and microbleeds) and amyloid burden (Pittsburgh compound B [PiB] retention ratio) contribute to cognitive impairment independently or interactively. We recruited 136 patients with subcortical vascular cognitive impairment who underwent magnetic resonance imaging, PiB-positron emission tomography, and neuropsychological testing. The number of lacunes was associated with memory, frontal dysfunctions, and disease severity. The volume of white matter hyperintensities and the PiB retention ratio were associated only with memory dysfunction. There was no direct correlation between CVD markers and PiB retention ratio except that the number of lacunes was negatively correlated with the PiB retention ratio. In addition, there were no interactive effects of CVD and PiB retention ratio on cognition. Our findings suggest that CVD and amyloid burden contribute independently and not interactively to specific patterns of cognitive dysfunction in patients with subcortical vascular cognitive impairment.

Original language	English
Pages (from-to)	254-260
Number of pages	7
Journal	Neurobiology of Aging
Volume	35
Issue number	1
DOIs	https://doi.org/10.1016/j.neurobiolaging.2013.06.026
State	Published - Jan 2014

Bibliographical note

Funding Information:
This study was supported by a grant from the Korean Healthcare Technology R&D Project , Ministry for Health, Welfare and Family Affairs, Republic of Korea (number A120798 , A102065 and A070001 ), Korean Science and Engineering Foundation (KOSEF) NRL program grant funded by the Korean government (MEST; 2011-0028333 ), Samsung Medical Center Clinical Research Development Program grant ( CRL-108011 and CRS 110-14-1 ), and Converging Research Center Program through the Ministry of Education, Science and Technology ( 2010K001054 ).

Keywords

Amyloid
Cerebrovascular disease
Cognition
Lacune
Microbleed
Pittsburgh compound B
White matter hyperintensity

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10.1016/j.neurobiolaging.2013.06.026

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Park, J. H., Seo, S. W., Kim, C., Kim, S. H., Kim, G. H., Kim, S. T., Jeon, S., Lee, J. M., Oh, S. J., Kim, J. S., Choe, Y. S., Lee, K. H., Shin, J. S., Kim, C. H., Noh, Y., Cho, H., Yoon, C. W., Kim, H. J., Ye, B. S., ... Na, D. L. (2014). Effects of cerebrovascular disease and amyloid beta burden on cognition in subjects with subcortical vascular cognitive impairment. Neurobiology of Aging, 35(1), 254-260. https://doi.org/10.1016/j.neurobiolaging.2013.06.026

@article{8ff61b46227040e3bcde69fb1406996a,

title = "Effects of cerebrovascular disease and amyloid beta burden on cognition in subjects with subcortical vascular cognitive impairment",

abstract = "Cerebrovascular disease (CVD) and amyloid burden are the most frequent pathologies in subjects with cognitive impairment. However, the relationship between CVD, amyloid burden, and cognition are largely unknown. We aimed to evaluate whether CVD (lacunes, white matter hyperintensities, and microbleeds) and amyloid burden (Pittsburgh compound B [PiB] retention ratio) contribute to cognitive impairment independently or interactively. We recruited 136 patients with subcortical vascular cognitive impairment who underwent magnetic resonance imaging, PiB-positron emission tomography, and neuropsychological testing. The number of lacunes was associated with memory, frontal dysfunctions, and disease severity. The volume of white matter hyperintensities and the PiB retention ratio were associated only with memory dysfunction. There was no direct correlation between CVD markers and PiB retention ratio except that the number of lacunes was negatively correlated with the PiB retention ratio. In addition, there were no interactive effects of CVD and PiB retention ratio on cognition. Our findings suggest that CVD and amyloid burden contribute independently and not interactively to specific patterns of cognitive dysfunction in patients with subcortical vascular cognitive impairment.",

keywords = "Amyloid, Cerebrovascular disease, Cognition, Lacune, Microbleed, Pittsburgh compound B, White matter hyperintensity",

author = "Park, {Jae Hyun} and Seo, {Sang Won} and Changsoo Kim and Kim, {Sook Hui} and Kim, {Geon Ha} and Kim, {Sung Tae} and Seun Jeon and Lee, {Jong Min} and Oh, {Seung Jun} and Kim, {Jae Seung} and Choe, {Yearn Seong} and Lee, {Kyung Han} and Shin, {Ji Soo} and Kim, {Chi Hun} and Young Noh and Hanna Cho and Yoon, {Cindy W.} and Kim, {Hee Jin} and Ye, {Byoung Seok} and Michael Ewers and Weiner, {Michael W.} and Lee, {Jae Hong} and Werring, {David J.} and Na, {Duk L.}",

note = "Funding Information: This study was supported by a grant from the Korean Healthcare Technology R&D Project , Ministry for Health, Welfare and Family Affairs, Republic of Korea (number A120798 , A102065 and A070001 ), Korean Science and Engineering Foundation (KOSEF) NRL program grant funded by the Korean government (MEST; 2011-0028333 ), Samsung Medical Center Clinical Research Development Program grant ( CRL-108011 and CRS 110-14-1 ), and Converging Research Center Program through the Ministry of Education, Science and Technology ( 2010K001054 ). ",

year = "2014",

month = jan,

doi = "10.1016/j.neurobiolaging.2013.06.026",

language = "English",

volume = "35",

pages = "254--260",

journal = "Neurobiology of Aging",

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Park, JH, Seo, SW, Kim, C, Kim, SH, Kim, GH, Kim, ST, Jeon, S, Lee, JM, Oh, SJ, Kim, JS, Choe, YS, Lee, KH, Shin, JS, Kim, CH, Noh, Y, Cho, H, Yoon, CW, Kim, HJ, Ye, BS, Ewers, M, Weiner, MW, Lee, JH, Werring, DJ & Na, DL 2014, 'Effects of cerebrovascular disease and amyloid beta burden on cognition in subjects with subcortical vascular cognitive impairment', Neurobiology of Aging, vol. 35, no. 1, pp. 254-260. https://doi.org/10.1016/j.neurobiolaging.2013.06.026

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T1 - Effects of cerebrovascular disease and amyloid beta burden on cognition in subjects with subcortical vascular cognitive impairment

AU - Park, Jae Hyun

AU - Seo, Sang Won

AU - Kim, Changsoo

AU - Kim, Sook Hui

AU - Kim, Geon Ha

AU - Kim, Sung Tae

AU - Jeon, Seun

AU - Lee, Jong Min

AU - Oh, Seung Jun

AU - Kim, Jae Seung

AU - Choe, Yearn Seong

AU - Lee, Kyung Han

AU - Shin, Ji Soo

AU - Kim, Chi Hun

AU - Noh, Young

AU - Cho, Hanna

AU - Yoon, Cindy W.

AU - Kim, Hee Jin

AU - Ye, Byoung Seok

AU - Ewers, Michael

AU - Weiner, Michael W.

AU - Lee, Jae Hong

AU - Werring, David J.

AU - Na, Duk L.

N1 - Funding Information: This study was supported by a grant from the Korean Healthcare Technology R&D Project , Ministry for Health, Welfare and Family Affairs, Republic of Korea (number A120798 , A102065 and A070001 ), Korean Science and Engineering Foundation (KOSEF) NRL program grant funded by the Korean government (MEST; 2011-0028333 ), Samsung Medical Center Clinical Research Development Program grant ( CRL-108011 and CRS 110-14-1 ), and Converging Research Center Program through the Ministry of Education, Science and Technology ( 2010K001054 ).

PY - 2014/1

Y1 - 2014/1

N2 - Cerebrovascular disease (CVD) and amyloid burden are the most frequent pathologies in subjects with cognitive impairment. However, the relationship between CVD, amyloid burden, and cognition are largely unknown. We aimed to evaluate whether CVD (lacunes, white matter hyperintensities, and microbleeds) and amyloid burden (Pittsburgh compound B [PiB] retention ratio) contribute to cognitive impairment independently or interactively. We recruited 136 patients with subcortical vascular cognitive impairment who underwent magnetic resonance imaging, PiB-positron emission tomography, and neuropsychological testing. The number of lacunes was associated with memory, frontal dysfunctions, and disease severity. The volume of white matter hyperintensities and the PiB retention ratio were associated only with memory dysfunction. There was no direct correlation between CVD markers and PiB retention ratio except that the number of lacunes was negatively correlated with the PiB retention ratio. In addition, there were no interactive effects of CVD and PiB retention ratio on cognition. Our findings suggest that CVD and amyloid burden contribute independently and not interactively to specific patterns of cognitive dysfunction in patients with subcortical vascular cognitive impairment.

AB - Cerebrovascular disease (CVD) and amyloid burden are the most frequent pathologies in subjects with cognitive impairment. However, the relationship between CVD, amyloid burden, and cognition are largely unknown. We aimed to evaluate whether CVD (lacunes, white matter hyperintensities, and microbleeds) and amyloid burden (Pittsburgh compound B [PiB] retention ratio) contribute to cognitive impairment independently or interactively. We recruited 136 patients with subcortical vascular cognitive impairment who underwent magnetic resonance imaging, PiB-positron emission tomography, and neuropsychological testing. The number of lacunes was associated with memory, frontal dysfunctions, and disease severity. The volume of white matter hyperintensities and the PiB retention ratio were associated only with memory dysfunction. There was no direct correlation between CVD markers and PiB retention ratio except that the number of lacunes was negatively correlated with the PiB retention ratio. In addition, there were no interactive effects of CVD and PiB retention ratio on cognition. Our findings suggest that CVD and amyloid burden contribute independently and not interactively to specific patterns of cognitive dysfunction in patients with subcortical vascular cognitive impairment.

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KW - Cerebrovascular disease

KW - Cognition

KW - Lacune

KW - Microbleed

KW - Pittsburgh compound B

KW - White matter hyperintensity

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DO - 10.1016/j.neurobiolaging.2013.06.026

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AN - SCOPUS:84885188433

SN - 0197-4580

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SP - 254

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JO - Neurobiology of Aging

JF - Neurobiology of Aging

IS - 1

ER -

Effects of cerebrovascular disease and amyloid beta burden on cognition in subjects with subcortical vascular cognitive impairment

Abstract

Bibliographical note

Keywords

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