Effects of catechol-O-methyltransferase Val158Met polymorphism on the cognitive stability and aggression in the first-onset schizophrenic patients

Hyun Han Doug, Seok Kee Baik, Joon Min Kyung, Sik Lee Young, Chul Na, Byung Park Doo, Kyoon Lyoo In

Research output: Contribution to journalArticlepeer-review

46 Scopus citations

Abstract

We assessed catechol-O-methyltransferase (COMT) polymorphism in 132 first-onset schizophrenic patients and 80 healthy controls. The relationship between COMT polymorphism and cognitive function, aggression and psychiatric symptoms was tested in the schizophrenic group. COMTL carrier had higher digit span score and lower similarity score than COMTH homozygote. COMTL carrier had higher attention and delusion scores and lower inappropriate affect scores than COMTH homozygote. Attention and delusion scores of COMTL allele were higher than COMTH allele. COMTL group had higher aggression than COMTH homozygote. Our results support the theory that COMT L allele was related with increased tonic dopamine activity and cognitive 'stability', which may induce cognitive inflexibility in schizophrenia.

Original languageEnglish
Pages (from-to)95-99
Number of pages5
JournalNeuroReport
Volume17
Issue number1
DOIs
StatePublished - Jan 2006

Keywords

  • Aggression
  • Attention
  • Catechol-O-methyltransferase
  • Cognitive stability

Fingerprint

Dive into the research topics of 'Effects of catechol-O-methyltransferase Val158Met polymorphism on the cognitive stability and aggression in the first-onset schizophrenic patients'. Together they form a unique fingerprint.

Cite this