Effects of adrenal androgen levels on bone age advancement in prepubertal children: Using the Ewha birth and growth cohort study

Research output: Contribution to journalArticlepeer-review

12 Scopus citations

Abstract

Bone age (BA) advancement in prepubertal children may be associated with earlier onset of puberty and obesity. This study aimed to define the effects of adrenal androgen levels on the advancement of BA in prepubertal children, independent of obesity. During July and August 2011, we examined BA in 200 prepubertal children aged 7-9 years who were part of the Ewha Birth & Growth Cohort Study. BA was assessed by the Greulich-Pyle method. An index of BA advancement was calculated as the ratio of BA to chronological age (CA) (BA/CA), and this ratio was classified into 3 tertiles. We analyzed the relationship between BA advancement and anthropometric characteristics and adrenal hormone levels. The number of overweight children increased from the first group to the third group (PTrend = 0.03). The levels of adrenal androgens showed a significant positive correlation with the tertile groups after adjusting for age and sex (testosterone: r = 0.26, P < 0.001; dehydroepiandrosterone: r = 0.21, P < 0.001; androstenedione: r = 0.20, P < 0.001). Further, after controlling for body mass index (BMI), sex, and age, the BA/CA was found to be positively correlated with androstenedione (β = 0.04, R2= 3.7%) and testosterone levels (β = 0.05, R2= 4.7%). Based on our results, it is suggested that adrenal androgen levels are associated with BA advancement independent of BMI.

Original languageEnglish
Pages (from-to)968-973
Number of pages6
JournalJournal of Korean Medical Science
Volume32
Issue number6
DOIs
StatePublished - 2017

Keywords

  • Adrenal cortex hormone
  • Bone age
  • Children
  • Obesity

Fingerprint

Dive into the research topics of 'Effects of adrenal androgen levels on bone age advancement in prepubertal children: Using the Ewha birth and growth cohort study'. Together they form a unique fingerprint.

Cite this