Effects of acetylbergenin against D-galactosamine-induced hepatotoxicity in rats

Hwa Kyung Lim, Hack Seang Kim, Hong Serck Choi, Seikwan Oh, Choon Gon Jang, Jongwon Choi, Seung Hwan Kim, Myung Jei Chang

Research output: Contribution to journalArticlepeer-review

55 Scopus citations

Abstract

The hepatoprotective effects of acetylbergenin were examined against D-galactosamine (GalN)-induced liver damage in rats, compared with that of bergenin reported previously. Acetylbergenin was synthesized from acetylation of bergenin, isolated from Mallotus japonicus, to increase lipophilic and physiological activities. Acetylbergenin was administered orally once daily for 7 days and then GalN (400 mg kg-1, i.p.) was injected at 24 h and 96 h after the final administration of acetylbergenin. Acetylbergenin reduced the elevated serum enzyme activities of alanine/aspartate aminotransferase, sorbitol dehydrogenase and γ-glutamyltransferase and the formation of hepatic malondialdehyde induced by GalN. Acetylbergenin also significantly restored towards normalization the decreased levels of glutathione and the decreased activities of glutathione S-transferase and glutathione reductase induced by GalN. Therefore, these results suggest that acetylbergenin has hepatoprotective effects against GalN-induced hepatotoxicity by inhibiting lipid peroxidation and maintaining an adequate level of GSH for the detoxification of xenobiotics as underlying hepatoprotective mechanisms. In addition, lipophilic acetylbergenin showed more activity in the hepatoprotection than that of the much less lipophilic bergenin reported previously. (C) 2000 Academic Press.

Original languageEnglish
Pages (from-to)471-474
Number of pages4
JournalPharmacological Research
Volume42
Issue number5
DOIs
StatePublished - 2000

Keywords

  • Acetylbergenin
  • D-galactosamine
  • Hepatoprotective effect

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