Effectiveness of capsule endoscopy compared with other diagnostic modalities in patients with small bowel crohn's disease: A meta-analysis

Miyoung Choi, Sungwon Lim, Myung Gyu Choi, Ki Nam Shim, Seon Heui Lee

Research output: Contribution to journalArticlepeer-review

20 Scopus citations

Abstract

Background/Aims: As a result of the rapid development of medical diagnostic tools, physicians require concrete evidence to evaluate the effectiveness of the tools. We aimed to investigate the effectiveness and additional diagnostic benefits of capsule endoscopy (CE) in patients with small bowel Crohn's disease (CD). Methods: We performed a systematic search of databases, including MEDLINE, EMBASE, and the Cochrane Library, as well as eight domestic databases. Two reviewers independently screened all references. Diagnostic data from the studies were collected, and a meta-analysis was performed. Results: Twenty-four studies were included. In cases of suspected CD, CE demonstrated a superior diagnostic yield compared with small bowel follow-through (SBFT) and enteroclysis (EC); however, there was no difference compared with computed tomography enterography or magnetic resonance enterography. In cases with established CD, CE demonstrated a higher diagnostic yield only compared with EC. In the detection of terminal ileum lesions, CE exhibited a significantly increased detection rate compared with ileoscopy. Conclusions: The findings of our meta-analysis indicate that CE is superior to SBFT and EC in the evaluation of suspected CD cases. CE is also a more effective diagnostic modality in patients with established CD compared with EC.

Original languageEnglish
Pages (from-to)62-72
Number of pages11
JournalGut and Liver
Volume11
Issue number1
DOIs
StatePublished - Jan 2017

Keywords

  • Capsule endoscopy
  • Crohn disease
  • Diagnostic yield
  • Intestine, small
  • Metaanalysis

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