Effective mixing in a microfluidic chip using magnetic particles

Seung Hwan Lee, Danny Van Noort, Ji Youn Lee, Byoung Tak Zhang, Tai Hyun Park

Research output: Contribution to journalArticlepeer-review

99 Scopus citations

Abstract

We present a novel active mixing method in a microfluidic chip, where the controlled stirring of magnetic particles is used to achieve an effective mixing of fluids. To perform mixing, the ferromagnetic particles were embedded and manipulated under the influence of a rotating magnetic field. By aligning the magnetic beads along the magnetic field lines, rod-like structures are formed, functioning as small stir bars. Under higher flow conditions the particles did not form the typical rod structure but rather formed aggregates, which were even more beneficial for mixing. Our system reached a 96% mixing efficiency in a relatively short distance (800 μm) at a flow rate of 1.2-4.8 mm/s. These results demonstrate that our mixing method is useful for microfluidic devices with low aspect ratios and molecules with large molecular weights.

Original languageEnglish
Pages (from-to)479-482
Number of pages4
JournalLab on a Chip
Volume9
Issue number3
DOIs
StatePublished - 2009

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