Effect of whole-body exposure to the 848.5 MHz code division multiple access (CDMA) electromagnetic field on adult neurogenesis in the young, healthy rat brain

Hye Sun Kim, Yeon Ju Kim, Yu Hee Lee, Yun Sil Lee, Hyung Do Choi, Jeong Ki Pack, Nam Kim, Young Hwan Ahn

Research output: Contribution to journalArticlepeer-review

3 Scopus citations

Abstract

Introduction: Whether exposure to the 848.5 MHz code division multiple access (CDMA) signal affects adult neurogenesis is unclear. Materials and methods: An animal experiment was performed with a reverberation chamber designed as a whole-body CDMA exposure system. Male Sprague-Dawley rats were assigned to three groups (n = 6 per group): Cage-control, sham-exposed, and CDMA-exposed groups. Rats in the CDMA-exposed group were exposed to the CDMA signal at a 2 W/kg whole-body specific absorption rate (SAR) for 1 or 8 h daily, 5 days per week, for 2 weeks. Rats received a single intraperitoneal injection of Bromodeoxyuridine (BrdU) to label proliferative cells daily for the last five consecutive days of CDMA signal exposure. An unbiased stereological method was used to estimate the number of BrdU+ cells in the subventricular zone (SVZ) and dentate gyrus (DG). Results: We found no significant changes in the number of BrdU+ cells in the SVZ or DG in the CDMA-exposed rats, compared with rats in the cage-control and sham-exposed groups (p > 0.05). Conclusion: Our results suggest that exposure to the CDMA signal does not affect neurogenesis in the adult rat brain, at least under our experimental conditions.

Original languageEnglish
Pages (from-to)354-359
Number of pages6
JournalInternational Journal of Radiation Biology
Volume91
Issue number4
DOIs
StatePublished - 1 Apr 2015

Keywords

  • Bromodeoxyuridine (BrdU)
  • Cell proliferation
  • Dentate gyrus
  • Neurogenesis
  • Radio waves
  • Rats
  • Subventricular zone

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