Effect of vitamin D deficiency in korean patients with acute respiratory distress syndrome

Sojung Park, Min Gi Lee, Sang Bum Hong, Chae Man Lim, Younsuck Koh, Jin Won Huh

Research output: Contribution to journalArticlepeer-review

15 Scopus citations


Background/Aims: Vitamin D modulates innate and adaptive immune responses, and vitamin D deficiency is associated with increased mortality in hospitalized patients with pneumonia. We evaluated the prevalence of vitamin D deficiency in Korean patients with acute respiratory distress syndrome (ARDS) and its effect on the clinical outcomes of ARDS. Methods: We retrospectively analyzed the data of 108 patients who had a measured serum level of 25-hydroxy vitamin D3 (25(OH)D3) at the time of diagnosis with ARDS. The clinical outcomes were evaluated based on 25(OH)D3 levels of 20 ng/mL and stratified by quartiles of 25(OH)D3 levels. Results: The mean age of patients was 59.4 years old; 77 (71.3%) were male. Vitamin D def iciency was found in 103 patients (95. 4%). The mean 25(OH)D3 level was 8.3 ± 7.0 ng/mL. Neither in-hospital mortality (40.0% vs. 68.0%) nor 6-month mortality (40.0% vs. 71.8%) significantly differed between groups. There were no significant differences in 25(OH)D3 level between survivors (8.1 ± 7.6 ng/mL) and non-survivors (8.5 ± 6.8 ng/mL, p = 0.765). There were no trends toward a difference in mortality among quartiles of 25(OH)D3 levels. However, 25(OH)D3 levels were inversely related with length of hospital stay and intensive care unit stay among in-hospital survivors. Conclusions: Vitamin D deficiency was prevalent in Korean patients with ARDS. However, levels of vitamin D were not associated with mortality. A large, prospective study is needed to evaluate the effects of vitamin D deficiency on clinical outcomes of ARDS.

Original languageEnglish
Pages (from-to)1129-1136
Number of pages8
JournalKorean Journal of Internal Medicine
Issue number6
StatePublished - Nov 2018

Bibliographical note

Publisher Copyright:
© 2018, Korean Association of Internal Medicine. All rights reserved.


  • Acute respiratory distress syndrome
  • Mortality
  • Prognosis
  • Vitamin D


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