Effect of vehicles and enhancers on the in vitro permeation of melatonin through hairless mouse skin

Sun Gwak Hye, Ung Kim Seung, Koo Chun In

Research output: Contribution to journalArticlepeer-review

22 Scopus citations

Abstract

The effects of vehicles and penetration enhancers on the in vitro permeation of melatonin through dorsal hairless mouse skin were investigated. Propylene glycol laurate (PGL), isopropyl myristate (IPM), propylene glycol monolaurate (PGML) and propylene glycol monocaprylate (PGMC) showed high permeation fluxes and PGL, PGML and PGMC decreased lag time significantly. In both of the binary co-solvents of diethylene glycol monoethyl ether (DGME)-PGL and DGME-IPM, the highest fluxes were achieved at 20% of DGME, which were 10.5±1.5 and 9.1 ± 2.4 μg/cm2/h, respectively. Among fatty acids used as a permeation enhancer, capric acid and oleic acid in DGME-PGL (80:20 v/v) showed relatively high enhancing effects. Capric acid also shortened the lag time of melatonin from 2.4 ± 0.7 to 1.3 ± 0.2 h. Oleic acid, however, failed to shorten the lag time. Therefore, for effective solution formulations in terms of permeation flux and lag time, capric acid-containing DGME-PGL (80:20 v/v) could be used to enhance the skin permeation of melatonin.

Original languageEnglish
Pages (from-to)392-396
Number of pages5
JournalArchives of Pharmacal Research
Volume25
Issue number3
DOIs
StatePublished - 30 Jun 2002

Keywords

  • Lag time
  • Melatonin
  • Penetration enhancers
  • Permeation fluxes
  • Vehicles

Fingerprint

Dive into the research topics of 'Effect of vehicles and enhancers on the in vitro permeation of melatonin through hairless mouse skin'. Together they form a unique fingerprint.

Cite this