Effect of time interval between breast-conserving surgery and radiation therapy on outcomes of node-positive breast cancer patients treated with adjuvant doxorubicin/cyclophosphamide followed by taxane

Hyeon Kang Koh, Kyung Hwan Shin, Kyubo Kim, Eun Sook Lee, In Hae Park, Keun Seok Lee, Jungsil Ro, So Youn Jung, Seeyoun Lee, Seok Won Kim, Han Sung Kang, Eui Kyu Chie, Wonshik Han, Dong Young Noh, Kyung Hun Lee, Seock Ah Im, Sung Whan Ha

Research output: Contribution to journalArticlepeer-review

10 Scopus citations

Abstract

Purpose This study evaluated the effect of surgery-radiotherapy interval (SRI) on outcomes in patients treated with adjuvant radiotherapy (RT) after breast-conserving surgery (BCS) and adjuvant four cycles of doxorubicin/cyclophosphamide (AC) followed by four cycles of taxane. Materials and Methods From 1999 to 2007, 397 eligible patients were diagnosed. The effect of SRI on outcomes was analyzed using a Cox proportional hazards model, and a maximal chi-square method was used to identify optimal cut-offvalue of SRI for each outcome. Results The median SRI was 6.7 months (range, 5.6 to 10.3 months). A SRI of 7 months was the significant cut-offvalue for distant metastasis-free survival (DMFS) and disease-free survival (DFS) using a maximal chi-square method. For overall survival, a significant cut-offvalue was not found. The patients with SRI > 7 months had worse 6-year DMFS and DFS than those with SRI ≤ 7 months on univariate analysis (DMFS, 81% vs. 91%, p=0.003; DFS, 78% vs. 89%, p=0.002). On multivariate analysis, SRI > 7 months did not affect DMFS and DFS. Conclusion RT delayed for more than 7 months after BCS and adjuvant four cycles of AC followed by four cycles of taxane did not compromise clinical outcomes.

Original languageEnglish
Pages (from-to)483-490
Number of pages8
JournalCancer Research and Treatment
Volume48
Issue number2
DOIs
StatePublished - 1 Apr 2016

Keywords

  • Adjuvant chemotherapy
  • Breast neoplasms
  • Radiotherapy
  • Segmental mastectomy
  • Time-to-treatment

Fingerprint

Dive into the research topics of 'Effect of time interval between breast-conserving surgery and radiation therapy on outcomes of node-positive breast cancer patients treated with adjuvant doxorubicin/cyclophosphamide followed by taxane'. Together they form a unique fingerprint.

Cite this