Effect of stress on the expression of Rho-kinase and collagen in rat bladder tissue

Hana Yoon, Donghyun Lee, Kyemin Chun, Hyunsuk Yoon, Jaeyeong Yoo

Research output: Contribution to journalArticlepeer-review

6 Scopus citations


Purpose: We examined the effect of stress on the pathophysiology of bladder stability in terms of enzyme levels, Rho-kinase, and bladder relaxation. Materials and Methods: A total of 48 female Sprague-Dawley rats were studied in scheduled stress environments for 7, 14, and 28 days; 24 rats were in the control group and 24 rats were in the test (stressed) group. Results: Estrogen decreased significantly whereas testosterone and dopamine increased significantly in the stress group (p<0.05). Rho-kinase was significantly increased in the rats exposed to stress stimuli for 14 days (p<0.05). Collagen types I and III in the bladder tissue were significantly higher in rats exposed to stress for 14 days and 28 days (collagen type I in the 14-day group, p<0.01; collagen type I in the 28-day group, p<0.05; collagen type III in the 14-day and 28-day groups, p<0.05). Voiding frequency increased significantly as the duration of stress exposure was prolonged, in addition to a significant decrease in volume per voiding (p<0.05). Conclusions: The changes observed in micturition pattern, factors that contribute to smooth muscle contraction, and relaxation in the female rat bladder support the hypothesis that stress affects bladder stability.

Original languageEnglish
Pages (from-to)132-138
Number of pages7
JournalKorean Journal of Urology
Issue number2
StatePublished - Feb 2010


  • Physiology
  • Urinary bladder


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