Effect of statins on the risk of poststroke pneumonia: National population-based cohort study

Tae Jin Song, Jinkwon Kim

Research output: Contribution to journalArticlepeer-review

4 Scopus citations

Abstract

Purpose: Statins are widely prescribed medications for treatment of dyslipidemia and prevention of cardiovascular disease. Beyond their lipid-lowering property, statins exhibit multiple pleiotropic and antimicrobial effects. We aimed to investigate the effect of statins on the long-term risk of pneumonia after acute ischemic stroke. Methods: This retrospective observational research was performed using South Korean National Health Insurance Service claim data, which consist of population-based random sampling. We included patients discharged with acute ischemic stroke (I63 in the ICD10) and no prior history of pneumonia. The primary outcome measure was the occurrence of pneumonia determined based on ICD10 code J09–J18. Treatment with statins during follow-up was collected as a time-dependent variable based on prescription records. Results: A total of 7,001 subjects with acute ischemic stroke and no prior history of pneumonia were included. During the mean 3.96-year follow-up, pneumonia occurred in 1,715 subjects (24.5%). On multivariate time-dependent Cox proportional hazard–regression analyses, significant preventive benefit of treatment with statins against pneumonia was noted (adjusted HR 0.86, 95% CI 0.77–0.97). Compared to no use of statin, adjusted HRs (95% CIs) for current use of low–intermediate high-intensity statins were 0.88 (0.78–-0.99) and 0.49 (0.27–0.87), respectively. Conclusion: Our retrospective national cohort study found reduced risk of poststroke pneumonia with statin therapy after acute ischemic stroke. Our study suggests that treatment with statins may have a preventive effect against the common complication of poststroke pneumonia.

Original languageEnglish
Pages (from-to)2689-2698
Number of pages10
JournalInfection and Drug Resistance
Volume13
DOIs
StatePublished - 2020

Bibliographical note

Funding Information:
Basic Science Research Program through the National Research Foundation of Korea funded by the Ministry of Education (2018R1D1A1B07040959 to T -JS). The funders had no role in study design, data collection and analysis, the decision to publish, or preparation of the manuscript.

Funding Information:
This study used NHIS-NSC data (NHIS-2019-2-059) from the NHIS. This work was supported by the Basic Science Research Program through the National Research Foundation of Korea (NRF) funded by the Ministry of Education (NRF-2017R1D1A1B03033382 to JK). This work was supported by a grant from the

Publisher Copyright:
© 2020 Song and Kim.

Keywords

  • Infection
  • Pneumonia
  • Statin
  • Stroke

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